8 Hour Prep Double Dose

[Temptationwaits]

Apologies for cross posting this as i also mentioned this in another thread about hiv risks from anal fingering. Its a prep discussion so posting it here in the hope of lots of feedback.

I had a hiv test today and the chap doing it mentioned prep.

He specifically said if you take a double dose of prep 8 hours prior to sex you are protected.

I had previously had understood you need to take it a few days before regularly to build up immunity.

I got the 8 hour info from the guy testing me at the Terence Higgins trust. This charity is at the forefront of hiv in the uk so would expect them to be very knowledgeable and up to date with their knowledge.

Anyone have info on this? Is this double dose 8 hours before as good as regularly taking single doses?

[BarebackFan]

Here's what I've been reading here in the US:

 

How soon after starting PrEP will I be protected? How long do I have to keep taking it to maintain that protection?

 

SEXUAL EXPOSURE

 

Before: The best available evidence suggests that, after starting daily Truvada, it takes 7 days to reach maximum protective effect against potential rectal exposures, 20 days for vaginal exposures. Investigation into this question is ongoing, and some researchers tell us that 7 days is conservative and there may be very good protection after only 4 days.

After: It is advised that you continue to take Truvada daily for 28 days after your last possible exposure to HIV. If you have an active hepatitis B infection, talk to your doctor before you stop Truvada. Stopping Truvada can cause active hepatitis B to get worse quickly.

Note for Transgender Men: we do not have good evidence about how well these guidelines may apply to you. The guidelines came from studies that were limited to cisgender men who have sex with men and cisgender and transgender women.

Non-daily Dosing: In a study called IPERGAY, researchers found that non-daily dosing was also effective for some people. CDC has not endorsed the IPERGAY regimen and recommends daily dosing for PrEP. For more information about the IPERGAY study, please click here:http://on.fb.me/1bF9HhV.

 

INJECTION EXPOSURE

 

There is no good data on how long you need to take daily Truvada in order to have protection against an injection exposure to HIV. It takes 20 days of daily dosing for Truvada to reach maximum concentration in blood. However, even at maximum concentration, we do not know how well, or even if, Truvada protects against acquiring HIV from an injection exposure. There have been no clinical studies that examined this. Nonetheless, CDC recommends PrEP for people who inject drugs (http://1.usa.gov/1HfclIQ).

 

Sources:

 

http://www.cdc.gov/hiv/basics/prep.html

http://www.ncbi.nlm.nih.gov/pubmed/25409469

http://cid.oxfordjournals.org/content/60/5/804.full.pdf

http://betablog.org/iprex-update-with-robert-grant/

[SethChase]

Do not double up, or skip doses. Take 1 dose daily. Otherwise your're playing russian roulette. At least that's how my Dr. put it. His practice is very experienced in HIV related treatment so I'm taking his advice, not that which I read on an Internet forum. 

[wood]

Do not double up, or skip doses. Take 1 dose daily. Otherwise your're playing russian roulette. At least that's how my Dr. put it. His practice is very experienced in HIV related treatment so I'm taking his advice, not that which I read on an Internet forum. 

 

Thats true, and misleading.  There are many proven studies so far that say 4x a week dosing provides protection very close to that of 7x a week dosing.  With that said, I wouldn't do it. 

 

As for the original question I just wouldn't do it.  IMO thats a quick way to mutated HIV strains.  

[mn6]

I wonder whether this is what the testing-center chap was referencing.

A short video by the new england journal of medicine regarding the efficacy of a sort of on-demand PrEP.  (December 2015 ANRS IPERGAY study)

I'm surprised it worked as well as it did.

http://www.nejm.org/do/10.1056/NEJMdo005041/full/