Generic Prep Dosage

[gay87]

Hi, im starting generic Prep , and I researched on the internet and found 3 types of recommended dosage

1) daily pill

2) alternate days 3-4 pills a week

3) 2 pills before sex( 24 hours apart), and 2 pills after (24 hours apart)

Any experts on the research of these 3 dosages? Any inputs from fellow prep takers?

[fillmyholeftl]

The daily pill is the only regimen that is approved by US FDA.  There is research from France I think, that supported the as needed dosing (your #3) I think it was 3 pills after.

Havent heard of your #2.  But after initial dosing, every other day would keep up some blood level of the drug but certainly would decrease the effectiveness

[Johnny84]

ya i take mine everyday 

[gay87]

Thanks all for valuable inputs, to back my 2nd option that Ive discussed..

http://www.hivandhepatitis.com/hiv-prevention/hiv-prep/5169-study-suggests-truvada-prep-should-start-1-week-before-and-continue-4-weeks-after-sex

http://www.thebodypro.com/content/74799/zero-hiv-infections-when-prep-is-taken-4-or-more-t.html

4.7/100 person-years if no drug was detected in DBS. (normalized risk was 4.7/100 person years, with 0 prep)

• 2.3/100 person-years if DBS indicated less than two tablets a week.
• 0.6/100 person-years if DBS indicated two or three tablets per week.
• 0/100 person-years if DBS indicated four to seven tablets per week.

I think I would stick to 'daily' dosage, while occassionally dont mind missing a dosage or 2 per week.

 

1 week before exposure, and 28 days after exposure? I think this is the conservative method?

However the France study, shows +3 pills after exposure might be sufficient