tonio

It would be interesting to know how long the Bexsero vaccine is good for gono partial protection.

You get two doses (the first dose at month 0, the second dose at month 6).

But do you need a booster? Like every 5 years?

On 11/30/2024 at 3:11 AM, Tiboer said:

I’ve met a number of closeted, married guys who use on-demand PrEP (2-1-1).  They get their PrEP through an online doc.  
 

Tonio, be sure to take 400 mg of Doxycycline too to prevent STIs

The recommended dosing for DoxyPEP is 200mg within 2 to 3 days

On 12/1/2024 at 2:02 AM, BootmanLA said:

How often do you take an on-demand dose set of PrEP? You say the last pill you took was Nov. 9. Do you (on average) take that 2-1-1 series once a week, once a month, every couple of months?

That, more than anything else, will determine if it's affecting your body in a way that routine lab work will detect. In other words, a 2-1-1 series of PrEP, once a month, is highly unlikely to cause, say, enough damage that it would be detectable on standard screening tests. If you were taking a series like that once a week, on the other hand, that's more than half of what someone taking it daily would be getting, so it's not impossible that (a) it MIGHT be affecting your liver or kidneys or whatever AND (b) that damage was beginning to show via lab work.

But the majority of people on PrEP, even taking it daily, don't have that kind of damage. So chances are pretty good that nothing will appear amiss.

That said: you don't say why you don't want your regular GP to know you're on PrEP. But if he doesn't, he may end up prescribing something else for you (for some unrelated illness or condition) that, in turn, interacts with your PrEP in a negative way, rendering it less effective. It's NEVER a good idea to hide medications prescribed by one doctor from another, particularly if the latter doctor is one you see regularly.

Basically I use on-demand PrEP about twice or three times a year. I don't use that many tablets (maybe 30 tablets a year tops).

Just received the bloodtest results, and kidney filtration function appears to be excellent. Nothing else to emphasize in the rest of the blood test.

So in my case, on-demand PrEP doesn't seem to affect kidneys.

11 minutes ago, NicNorth said:

I’m not an expert but I rather think that (partially due to costs) the tests you describe only detect the things they are designed to test for. My GP tests me for both of the things you list but has no knowledge of my taking PREP.  I’ve seen the resulting report which only appears to relate to the aspects of kidney function and blood sugar.  
 

To satisfy your self fully it’s worth contacting the PREP prescriber. 

Yeah, but my question is: how likely is it that the blood test is gonna detect something weird that could be related to me taking PrEP?

Hello,

I take on-demand PrEP (Truvada) through a specific GP (specialised in STDs) and the last pill I took was on Saturday, November 9. 

Now, I have to do a blood test for a completely unrelated reason (I have to test for glucose and kidneys) through my regular GP. The blood test is scheduled tomorrow, on November 30.

How long is Truvada detectable in the blood after last intake? My regular GP doesn't know anything about the fact I take Truvada, and I wouldn't like to disclose to him that information.

Is Truvada gonna be detectable in my blood 3 weeks after the last pill?

15 hours ago, hntnhole said:

What would circumcision have to do with it in the first place? 

Assuming that hideous act was performed (typically at an extremely early age - as in days, not years after birth), and long before the dick was used for anything other than to piss through.  

I would imagine that the chances a bug can be contracted by a Cock - circumcised or un - are pretty much equal.  

According to the WHO, VMMC (voluntary medical male circumcision) reduces the chance of HIV infection by 50-60% for heterosexual/insertive sex. There are biological reasons to believe these findings also apply to total tops.

[think before following links] [think before following links] https://www.who.int/publications/i/item/9789240072312

10 hours ago, Leather69 said:

I'm circumcised.. cock pierced with a Prince Albert (pa)

Maybe the piercing had some role in your infection (maybe your penis bled during sex?). Hepatitis C is pretty difficult to transmit sexually, especially if HIV negative.

7 hours ago, Leather69 said:

Yep..on PrEP and negative.  It was the friday night orgy during the folsom weekend. My pierced cock went into at least a dozen holes during the night.

Pierced? As in uncircumcised but with a piercing, or circumcised without a piercing?

12 hours ago, BootmanLA said:

As you noted, as a top-only guy, this may be enough to protect you. But it does require a great deal of planning ahead, knowing which days you plan to have sex. If you don't have at least four or five days' notice, it's impossible for this scenario to play out. If you're that sure that far ahead, more power to you.

I pretty much agree.

FWIW, I'm on Truvada, not Descovy (because Descovy is not covered by insurance where I live). But it's not really a problem as I almost don't experience sides with my modified Truvada on-demand regimen.

I have heard that Descovy was better tolerated than Truvada in most people.

On 5/16/2024 at 2:41 AM, Leather69 said:

I did.. fucking around in Barelin during folsom 9 years ago.

Were you a circumcised total top on PrEP/HIV-negative at the time of the infection with hep C?

UPDATE: 

Apparently, a booster is now recommended for those who got the two mpox shots more than 2 years ago.

3 hours ago, 1Exhibitionist said:

Does taking the dose with food alleviate or worsen your stomach issues?

I’m on a daily regimen and notice less stomach rumble when I’ve eaten something a few hours before my dose vs taking on an empty stomach.

Yes. Starting four days before with a reduced dose, taking the pill with food and crushing the pill with my teeth before swallowing it seemed to help. I think it's a combination of all these three factors because food or not, the initial double dose seemed to be overwhelming for my stomach.

The reason my physician allowed me to go on this regimen is because I am a circumcised total top. In his view, in my situation, even a low level of PrEP in my system would be sufficient to prevent a potential infection, provided I took care of other STDs and cuts/abrasions. The initial double dose is particularly efficient for bottoms though, he said.

So I guess I will just stick with this modified on-demand regimen + DoxyPEP if needed

Okay so here is my current on-demand PrEP regimen as discussed and modified with my physician.

My main problem seemed to be that the initial doses (especially the first double dose) were too much for my stomach.

So instead of the 2-1-1 standard on-demand regimen, I was allowed to use an alternative 0.5-0.5-0.5-0.5-1-1-1 regimen.

That is:

- Four daily 0.5 doses on the four days preceding the sexually active day (to get the drug progressively into my system without hurting my stomach too much)

- One full dose on the sexually active day

- One full dose on the next day

- One final full dose on the following day

Doing this (and always crushing the pill with my teeth before I swallowed it) seemed to reduce my gastrointestinal issues to almost nil while maintaining a good level of protection.

I post this for information only, always do things with the permission of your physician.

Hello,

I recently tried PrEP for the first time, on an on-demand basis (2-1-1 dosage).

And it was just awful.

It felt like I had the stomach of a 80-year-old.

I couldn't drink, even one beer. And even if I took the pills with a meal, I experienced pretty nasty stomach discomfort.

What's the point of being immune to HIV if you can't even enjoy to party and play?

So I stopped the medication, and quickly recovered (about 2 days after stopping medication).

Now I am talking about alternative options with my physician (maybe going for a 1-1-1-1-1 dosage to decrease side effects).

Anyone else experienced stomach issues linked to on-demand PrEP?

FYI, my doctor confirmed to me that the 2-dose vaccination scheme against mpox was effective for a lifetime. Just got my second jab.

Hello everyone,

We all know the hepatitis A/B vaccines provide lifetime protection after 2 or 3 doses.

But what about the HPV vaccine (gardasil, 3 doses) and the mpox vaccine (jynneos, 2 doses)?

Do they provide lifetime protection, or will we have to get booster doses after 5, 10 or 15 years?

22 minutes ago, Bimarried001 said:

To me that’s like a weed smoker voting for a candidate that is running on banning weed. 

You are entitled to your own opinion, but I humbly believe this is slightly exaggerated. In fact, some staunch Republican supporters are gay, like Peter Thiel or Scott Presler. Being LGBT+ doesn't require us to be woke advocates or to support a specific political agenda, especially in the free West. This is not Russia or Saudi Arabia.

I voted for Clinton in 2016, and did not vote in 2020 btw (liked Trump foreign policy but at the same time didn't want to vote for him). But the problem with the current Dems is that their aim is not to DO GOOD THINGS, but to APPEAR AS THE GOOD ONES. And that I cannot stand, especially after the Biden-sponsored genocide in the Middle East: at this precise moment, for the first time of my life, a vote for Trump wasn't out of the table. So yeah, having mean tweets in exchange of world peace and prosperity seems like not that bad of a deal honestly.  Just my two cents, not gonna dwell on this topic, this is my final message.

On 2/27/2023 at 7:29 AM, Poz50something said:

OK first of all, you're saying that circumcision prevents HIV - so why then, in the years before tritherapy did so many of our friends and so many porn stars die of AIDS? It's anecdotal, but a large majority of the US porn actors of the '70s were circumcised, and many of them aren't alive because they died of AIDS. If circumcision prevents HIV, why the high rates of HIV/AIDS among msm? You indicated that "its limitations are substantial".....follow your own logic.

Because most gay/bi guys aren't total tops.

Circumcision only protects total tops, and said protection is incomplete (about 60%).

1 hour ago, 50latinos said:

I am glad to be able to say I don't know any and can't imagine any reason why any LGBTQ person would do such a thing.

That's a perfectly understandable statement. But believe me, we exist (lol). This is not a political website so I am not going to elaborate on "why", but it's interesting to see that even here, we find some diversity in that regard. 

Hey everyone

Does anyone in here know a LGBT+ individual who's gonna vote R next November?

I happen to be one of them and I have some friends who are the same, but it seems like we are a silent minority.

Not here to offend anyone, just to know if you also experienced this.

Hey everyone,

I am looking for testimonies of circumcised total tops (on PrEP/HIV-negative) who got infected by hep C.

Is it actually possible? If so, what are the odds?

Thanks

Hi again,

So here is my final strategy to avoid HIV/most STDs. Maybe it could inspire some of us here:

- Lube

- Vaccines against hepatitis A/B + HPV + mpox + meningitis B (the Bexsero meningitis B vaccine offers a 50% protection against gono) + normal vaccines from calendar

- Circumcision

- Avoiding high-risk behavior (e.g.: no receptive anal whatsoever as I am a total top). Because hepatitis C is easily transmitted this way and there is no vaccine against it (curable but a pain in the ass)

- PrEP on demand (on vacation as I only bareback on vacation) + DoxyPEP + full testing (STDs, kidneys, liver) twice a year

I will keep you updated on this thread in case I still catch something despite this comprehensive strategy.

7 hours ago, rawfuckr said:

In my risk calculations I had put "getting hep C" as a far far far possibility. "it's a thing for people who inject drugs mostly and the fisters" I thought 

But here I am. Diagnosed with hep C and brutal viral load of 20milion/ml, and my liver markers (alt) off the measurable range for the tests

If something is certain is that I know 100% sure I got this from getting bred. I don't do drugs nor fist. Just normal fucking. So it's the only vector that makes sense. 

I feel stupid for having caught it. Always thought of hep C as an impossible possibility. I was clearly wrong. 

There's supposed to be a treatment for me, but even that seems complicated. Will insurance pay? Epclusa is 75k, mavyret 30k...

I'm scared and now I may  have to  live with hep c  due to my stupidity ....

If you bottom bareback, you're at risk for hep C. Period. Unfortunately there is no vaccine yet but the current treatments make it curable in about 8 weeks time.

[think before following links] https://www.nbcnews.com/health/sexual-health/gonorrhea-treatment-new-antibiotic-shows-promise-drug-resistant-infect-rcna123390

New antibiotic shows promise for drug-resistant gonorrhea

“Zoliflodacin gives us a new tool in the treatment of gonorrhea, and if used wisely, a barrier against the further spread of resistant infections,” said Dr. Jeffrey Klausner, an infectious disease expert at the Keck School of Medicine of USC, who was not involved in the trial.

The antibiotic, which would be the first new gonorrhea treatment approved in decades, could make it to market by 2025.

21 hours ago, Spunkinmyarse said:

Gonorrhea will be your biggest enemy- DoxyPEP is not very effective against it. But you’ll just have to deal with it as and when it appears- at least as a top, you’ll probably know when you’ve got it. But you should still get tested regularly.

They say that peeing after sex helps, but I’m not sure if there is any evidence for that.

Spot on. According to clinical data, DoxyPEP reduces odds of syphilis and chlamydia by about 90%, but only by 50% or so for gonorrhea. 

Gonorrhea is no fun, but a new oral antibiotic against drug-resistant gono has been found:  [think before following links] https://www.nytimes.com/2023/11/10/health/gonorrhea-treatment-zoliflodacin.html No need to get a sting up your ass like with current treatments.

Moreover, therapeutic HPV/herpes vaccines are currently prepared and should be released in 2025 or so.

Finally, as I am a circumcised total top, my risk for HIV and genital herpes are already lowered by 40-60% (but with PrEP, HIV is nothing to worry about anyway).