One area i don't see discussed much is side effects to Truvada when using OTC supplements. My I.D. Dr. at South San Francisco Kaiser dropped me from Truvada as I had high creatine level. She never asked me about the impact this would have on me. It wasn't until I STOPPED ALL supplements (including ibuprofen) for a surgical procedure and subsequent kidney test that my levels returned to normal (still taking Truvada at the time!). I'm now "challenging" the previous results in hope she'll get on my side of this topic and work with me to prescribe the drug. To her credit, however, she passed along a study (http://www.cdc.gov/nchhstp/newsroom/2015/IPERGAY-2015-Media-Statement.html) where "..findings combined with other recent research suggests that even with less than perfect daily adherence, PrEP may still offer substantial protection if taken consistently". The take home for me is our Dr's need education about outlying factors of side effects and we need to educate THEM on what it means to be in our position.