HungLatinDom

Well, we all drop the ball every now and then. They have done it before, with "the year of living positively". They did not release even a single movie with that subject. And now London Cum Junkies. I guess it happens a lot when you are too controversial, some things can get you in trouble sometimes. In any case, I think that they are a bit too desperate for controversy these days, and their porn suffers because of that.

I follow porn releases even if I don't watch most of the movies, and the latest release of TIM is deeply disturbing. If someone posted this type of thing here, as a mod, I'd block the post and move it to the Backroom. I remember feeling the same vibe from posts from guys that we ended up banning because they were crazy.
 

And they have announced a couple of movies that never were released (including a preview where a guy is snorting powder from another guy's cock). I can see that their business model is to be controversial and create shock, but I think that they are jumping the shark and dropping the ball in some things. I wonder what's going on in there.

Great. I hope to see you there

Hey there, guys
Is any of you going to Wet and Hot?

It's a piss party, but lots of barebacking, felching fisting and many other fetishes. It's organized by the guys of Dick Wadd Productions.

wetnhot.net

If any hairy pig is coming this year, let me know, as I am going to be there with my husband, giving loads and piss and lending a hand to those in need.

 

Suicide, not murder:

http://www.medpagetoday.com/HIVAIDS/HIVAIDS/43520

What's interesting here for me, is that shows that a fairly small amoun of cells are infected. If we knew how, we could nuke them and cure HIV. Some experimental therapies are focusing on this, but the big question was, how many remaining cells we would have.

This is the text of the article:

"In uncontrolled HIV infection, an over-the-top immune response causes much of the damage that leads to AIDS, researchers are reporting.

The process is "much more of a cellular suicide than a viral murder," according to Warner Greene, MD, PhD, of the Gladstone Institutes and the University of California San Francisco.

In papers in Nature and Science, Greene and colleagues outline -- for the first time -- how resting CD4-positive T cells die in response to HIV infection.

It's a "very new perspective," Greene told MedPage Today, and one that could very quickly lead to new therapeutic and perhaps even curative approaches.

The findings are a significant advance in the understanding of HIV pathophysiology, commented Demetre Daskalakis, MD, of Mount Sinai Hospital in New York City.

Even more than 30 years into the HIV/AIDS pandemic, he told MedPage Today, "it's remarkable that a lot is not known about how the very important cells in the immune system are actually depleted."

He added that it is likely that work will lead to advances in therapy. "Understanding HIV biologically is how you translate that to clinical innovation," he said.

HIV replicates by infecting activated CD4 T cells, which then produce copies of the virus and eventually die of programmed cell death, or apoptosis.

But if that were all, Greene said, they could easily be replaced by resting cells, which make up 95% of the targets encountered by the invading virus.

Instead, the resting cells also die, in what he called a "vicious pathological cycle."

In a series of experiments, he and colleagues show that the resting cells are the targets of "abortive infection," which cannot lead to fully formed HIV particles because the cells are not activated.

Instead, fragments of HIV DNA are scattered around the cell, eventually attracting the attention of a sensor molecule, interferon-gamma-inducible protein 16, or IFI16.

IFI16, the subject of the Science paper, initiates a process of cell death, mediated by the enzyme caspase 1 -- a molecule whose functions are the topic of the Nature paper.

Apoptosis in productively HIV-infected T cells, Greene and colleagues found, is mediated by another enzyme, caspase 3.

That form of cell death, Greene told MedPage Today, is a "very bland and silent process."

In contrast, the cell death of an abortively infected T cell -- dubbed pyroptosis -- is a dramatic event, spilling the cell's contents and proinflammatory cytokines, including interleukin-1β.

The result is inflammation, which draws more CD4 T cells to the area, where the HIV is waiting to repeat the process.

"It's as if the cavalry rode in and then turned their rifles on themselves," Greene said.

The good news is that blocking the activity of caspase 1 prevents the cell death and subsequent inflammation, at least in tissue experiments in the lab.

Moreover, at least one caspase 1 inhibitor -- a drug known as VX-765 -- is available and has been found safe and effective in clinical trials, albeit in epilepsy and psoriasis.

The researchers found that, in their tissue experiments, VX-765 effectively blocks caspase 1 activity, CD4 T cell death, and the release of interleukin-1β.

Greene said he and colleagues are working with the drug's maker and are eager to move into human trials in HIV.

If caspase 1 inhibitors prove as effective in the real world as in the lab, Greene said there is a range of possible uses.

In the developing world, he noted there are some 16 million people with HIV who do not have access to triple-drug antiretroviral therapy.

If a caspase 1 inhibitor were cheap, widely available, and easy to take, it might form a "sheltering place" -- slowing the progress of HIV while people waited for antiretroviral drugs.

Even for people with access to drugs, treatment is sometimes problematic because of resistance or other issues and caspase 1 blockers might be of value for them, Greene said.

Finally, there's evidence that inflammation drives the release of cytokines that in turn drive the proliferation of memory T cells.

Memory T cells form the so-called reservoir of HIV that allows it to return whenever antiretroviral therapy is stopped.

Caspase 1 inhibitors, he speculated, might be part of a cocktail of drugs that would lead to the "slow destruction" of the reservoir and the eventual clearance of HIV.

Indeed, that might be the most promising part of the research in the long term, Daskalakis commented.

"We know that the way to treat HIV is to give a full antiretroviral regimen," he said, and it's unlikely that caspase 1 inhibitors would replace that approach.

But the resting and memory cells are "the untapped targets" of HIV therapeutics. "If a cell is replicating actively, we know how to shut down HIV in that cell," he said. "But what we don't know ... is how to focus on depleting" the resting and memory cells.

A good understanding of that process might "really be the answer to drive the cure agenda," he said.

Greene also noted that people with HIV -- even if it is well-controlled -- have chronic inflammation that is thought to drive higher rates of other forms of illness, such as cardiovascular disease. Blocking caspase 1 might reduce that inflammation and prevent some of the so-called diseases of aging that appear to strike HIV-positive people earlier than others, he argued.

"If the biology leads us to a place where we can reduce inflammation," Daskalakis commented, "I think we're going to see better HIV outcomes with antiretrovirals.""

After 5 years, my VL is 14000, it came down from 15000, and my T cells are 850, pretty much what they were 6 months ago. I am not, never have been on meds. I consider myself very lucky, as I have known some people that got infected about the same time I was and they died already. I also have lost 3 friends while I have been here in Santiago.

Hell yes!

I want 4 shirts, if possible.

Size: medium

T-Shirt Color: 2x black, 2x burgundy

Front Graphic: 2x Raunchy Fuckers, 2x rawTOP

Front Graphic Color: Up to you

Rear Graphic: small biohazard, small rawTOP logo

Rear Graphic Color: Up to you

Thanks a lot!

They make a wonderful couple, I'd LOVE to see them again on camera, and of course, to do a nasty threesome! His Daddy was super hot.

Ah, I thought he was another one with a similar story who is about 28 (this is like the fourth case). Still, I was not an asshole when I was his age and there are a lot of really cool guys his age. No generalizations are needed.

RawTOP: That's not the only case when patients would be willing to take extra risks, but the current status quo won't let them make that choice. I have a few friends working in immune-system approaches for cancer. There's actually a lot of people willing to try anything for having a chance, yet, according to current regulations, patients HAVE to have access to the best available treatment at the same time. But chemo/radio wrecks your immune system completely. So, the proposed treatment can't be tried.

We need a less paternalistic approach to these issues. I am a scientist, and I believe that people have the right to be informed and make choices.

guys his age millennials or whatever they are called have had it so easy growing up parents who gave them money so they never had to work so they think HIV can be cured by taking a pill and that the world is theirs cause their shit don't stink. They are the same ones who protested today cause they feel that dishing out attitude along with a fucked up order at Taco Bell is worthy of $15.00 an hour. So heaven forbid anyone trying to tell them what to do. Jackson is probably one of those thinks he can get out of his contract by playing dumb. Time to grow up boy!

Would love to see them do a movie with the older guys teaching the young twinks bitches a thing or two about respect, and a hard days work in this case getting thier asses bred gang bang style. Putting the bitches in thier place. LOL

Please, don't generalize about people. I am about the same age, and I think what he did is hideous and cowardly.

So, chill out and direct complains to specific people, not to a whole group of us. You, older people, are supposed to be wise. Show it.

I guess I am a multi tasker. I love doing it, beyond hot. Not acrobatic at all.

I am almost 100% smooth (Native South American ancestors + European without a lot of hair, it seems), and I just can't get enough of rimming and fucking hairy asses

I have seen quite a bit of porn, and I haven't seen a lot of a top fisting two guys at the same time while fucking another. In real life, I have done it just a few times, it's difficult enough to find 2 fisting bottoms willing to share cock and hands. The first time, it was with my boyfriend, I fucked him while fisting the two guys.

I was in Vancouver for 2 weeks for a conference, some pigs were anxious waiting for my cock and seed, so I rounded 4 of them and fuck them at the same time. Here are some pictures.

https://www.breedingzone.com/album.php?albumid=4436

Have you done it at all? Interested in doing it?

I will be in Vancouver for a few days in mid-August

Anybody interested in getting together? I like hairy, muscular, masculine men who are kinky submissive in bed. Poz and not on meds yet (low VL, lots of CD4 cells). HungLatinDom on BBRT, Estwald on ManHunt and AssPig.

Any suggestions about places to visit?

And, if anybody is willing to offer a couch for dick, I'll be more than happy to do it!

Estwald .

Yes, I host the parties at my apartment in Bellas Artes. Any pics or profiles where I can see you?

Parties range from 6 to 20 guys, depends on the night...

Woof, Jake, that's really hot. I love to share piss when I am giving it to my bottom, don't swallow it all and give me back a bit. or spit it on me. and lick me afterwards. I'll lick the bottom if he gets sprayed.

It's so good to see you here, BTW.

I met you and your partner at a CumUnion party at Mack's Folsom prison in SF. I am that guy that fucked you both and asked to felch you when you were leaving, IIRC, I got five loads out of you.

Mononucleosis?

Don't think it's surprising....there is lots of drugs going on and loneliness.... It's all fine when u r at ur peak.... But after that u r yesterday's meet... No decent guy wants relationship with u as u have done porn....so yeah.... I can understand that it gets lonely...

I guess I am not a decent guy. I would have nothing serious with a decent guy, either.

Thanks HLD....facing HIV can be a scary proposition. I found the best way for me to handle it was to learn as much as I could about it. I guess the idea is if I can wrap my head around it, I can beat it. As you can tell, I'm a bit of an over-intellectualizing and analytical type LOL.

Exactly my position. I was very happy about being a biologist when I got infected. It gave me calm and a sense of control.

This year and the last one has been specially bad.

Not only Miklos, but Wilfried Knight, Adam Faust (a fantasy of mine), Erik Rhodes a guy whose name I don't remember in NYC and Josh Weston have died/committed suicide (and I am not sure if failing to take your HIV drugs is not a form of suicide).

And I am concerned about Pete Finland also, he dropped from all social media, and I tried to call him to his number, but it was disconnected.

It's not only an Italian word, you know...

Ciao is italian word not Spanish.

Man, that's a very, very helpful post. Thank you so much for putting time and effort on this.

One of the reasons why I love this forum.

Here's what you need to know about your two numbers:

Viral Load is a measure of how many copies of the HIV virus they find in your blood. Broadly speaking, it tells you how quickly the virus is reproducing. The higher the number, the further along your infection is. You want this number to be as low as possible; "undetectable" currently means less than 50 copies. Note that you can be undetectable for years, but you're still infected; HIV hides out in a number of places in the body, and while the HIV drugs stop it from reproducing, it doesn't actually kill the virus that's already there.

Sometimes, because the viral load can get very high (millions or even billions of copies), this number is expressed as a logarithm.

CD4 count refers to the number of CD4+ T helper cells in your blood sample. These cells are basically the mastermind of your active immune system. They are the ones that will trigger an immune response to an infection (specifically, they trigger B lymphocytes to produce antibodies--proteins that bind to and either kill viruses and bacteria or tag them for destruction and also what the HIV test looks for--and trigger CD8+ T killer cells which will destroy infected cells). Remove these cells from the picture (which is what HIV does) and your immune system will no longer respond to infections. These so-called "opportunistic infections" are what actually kills you.

Your CD4 count will naturally vary quite a bit depending on a number of factors. Age, general overall health, mood, exercise, sleep, diet, genetics...all of these things can have an impact on how healthy your immune system is and how well it will stand up to the HIV infection. Like Tiger said, 450 is a bit low, but you're still OK. In general, the CDC recommends that treatment start at the latest when your CD4 count drops to 350 or below. However, there is some research that suggests that earlier intervention is better...by starting treatment while your CD4 count is still relatively high you're setting a good baseline.

***

In general, the magic number for HIV treatment is three drugs that attack the virus in three different ways. HIV mutates extremely easily, which is why early drugs that successfully stopped HIV in the lab didn't work for very long in patients when given by themselves. What happened is that the AZT would stop the virus from reproducing for a short time, but it would mutate, become resistant to AZT and then start growing again.

The three HIV drugs in Stribild attack two of the proteins that HIV uses to reproduce. One is an integrase inhibitor, which the virus uses to transfer its genetic material into the chromosome of the cell it has invaded (it integrates it into your cellular DNA, hence the name). Stop the integrase, and the virus cannot insert itself into your DNA, which means it's blocked from reproducing (viruses reproduce by hijacking your cells and getting them to make copies of the virus rather than reproducing themselves). Integrase inhibitors are a relatively new class of drugs; they've only been on the market for the last five years or so.

The other two HIV drugs in Stribild attack a different protein called reverse transcriptase. Reverse transcriptase is a protein used by the virus to convert HIV's RNA into DNA that can then be integrated (via integrase) into the cell's own DNA. Each of the two drugs attack reverse transcriptase in different ways (there are three subclasses of reverse transcriptase inhibitors). This class is the oldest class of HIV drug; one of the drugs in Stribild is actually closely related to the very first HIV drug, AZT.

So the bottom line here is that you must have (at least) three different drugs attacking HIV in three different ways in order to control it. Any less than that, and HIV will eventually mutate and become resistant to those drugs. Worse, that resistance is inherited, meaning that those particular drugs will never work again on your virus. And even worse still, in general, if your virus acquires resistance to one drug, then it acquires resistance to all other drugs in the same class.

So a lot of HIV research has focused on two areas: first, developing medications within existing classes that are easier to take (may be taken fewer times per day, fewer side effects, etc.); second, developing new classes of medications that attack HIV in new ways (like integrase inhibitors vs. the three kinds of reverse transcriptase inhibitors; in addition, there are other classes that your doctor is holding in reserve for you, like protease inhibitors, fusion inhibitors, etc.). Having a wide range of medications in each class, and a wide range of classes increases the arsenal we can throw at the virus. The wide range of medications within a class means we can look for a medication that will be easy for you to take. And lots of classes means that we have fallback positions should you acquire resistance to one or more of your meds.

Over time, we've identified certain combinations that work particularly well for many people. The drug companies have conveniently bundled these into single pill formulations to make things even easier for you. These are once-a-day regimens that have few side effects for most people. Stribild is one example; Atripla and Complera are others.

***

So what should you be doing?

Your part in your therapy is twofold: 1) prevent resistance and viral mutation. 2) maintain your immune system

The most important thing you can do is prevent HIV from becoming resistant to your drug regimen. You do this by taking your medications as prescribed consistently. Skipping doses allows the virus to start growing again. This in turn gives the virus a chance to gain resistance to the drugs you have been taking.

Ask your doctor questions. What side effects can I expect? Will they get better with time? Are there any life-threatening side effects? When should I take the drug? Should it be taken with food or without or does it matter?

Monitor your side effects. If they are difficult to live with, do not stop taking the drug (unless it's a life threatening side effect; then go to the hospital immediately). Report the side effect to your doctor. He or she will work with you if they are causing you serious problems. This generally means finding a different drug that may be easier for you to take. Remember, you're looking for a drug combination that will work for you indefinitely; I've been going strong on mine for about ten years now.

Don't try to tough it out. I made this mistake early on. I didn't report some pretty difficult side effects, figuring that I could handle it. I couldn't, ended up skipping doses, and now I'm resistant to two medications.

Remember, keeping your meds with you requires some advance planning. If you will be traveling, bring everything you need plus some extra. You should never be without at least a one month supply unopened. You should never be caught in any situation where you might run out of your meds.

As for maintaining your immune system, this is all of the good advice doctors give us that we never take.

• Eat a healthy diet, including lots of fruits and vegetables
  
• Get eight hours of uninterrupted sleep every night
  
• Exercise regularly
  
• Avoid recreational drugs, including alcohol and tobacco (many actively disrupt the immune system)
  
• Maintain good, positive mental health; seek help if necessary