HungLatinDom

Well, we all drop the ball every now and then. They have done it before, with "the year of living positively". They did not release even a single movie with that subject. And now London Cum Junkies. I guess it happens a lot when you are too controversial, some things can get you in trouble sometimes. In any case, I think that they are a bit too desperate for controversy these days, and their porn suffers because of that.

I follow porn releases even if I don't watch most of the movies, and the latest release of TIM is deeply disturbing. If someone posted this type of thing here, as a mod, I'd block the post and move it to the Backroom. I remember feeling the same vibe from posts from guys that we ended up banning because they were crazy. And they have announced a couple of movies that never were released (including a preview where a guy is snorting powder from another guy's cock). I can see that their business model is to be controversial and create shock, but I think that they are jumping the shark and dropping the ball in some things. I wonder what's going on in there.

Great. I hope to see you there

Hey there, guys Is any of you going to Wet and Hot? It's a piss party, but lots of barebacking, felching fisting and many other fetishes. It's organized by the guys of Dick Wadd Productions. wetnhot.net If any hairy pig is coming this year, let me know, as I am going to be there with my husband, giving loads and piss and lending a hand to those in need.

Suicide, not murder: http://www.medpagetoday.com/HIVAIDS/HIVAIDS/43520 What's interesting here for me, is that shows that a fairly small amoun of cells are infected. If we knew how, we could nuke them and cure HIV. Some experimental therapies are focusing on this, but the big question was, how many remaining cells we would have. This is the text of the article: "In uncontrolled HIV infection, an over-the-top immune response causes much of the damage that leads to AIDS, researchers are reporting. The process is "much more of a cellular suicide than a viral murder," according to Warner Greene, MD, PhD, of the Gladstone Institutes and the University of California San Francisco. In papers in Nature and Science, Greene and colleagues outline -- for the first time -- how resting CD4-positive T cells die in response to HIV infection. It's a "very new perspective," Greene told MedPage Today, and one that could very quickly lead to new therapeutic and perhaps even curative approaches. The findings are a significant advance in the understanding of HIV pathophysiology, commented Demetre Daskalakis, MD, of Mount Sinai Hospital in New York City. Even more than 30 years into the HIV/AIDS pandemic, he told MedPage Today, "it's remarkable that a lot is not known about how the very important cells in the immune system are actually depleted." He added that it is likely that work will lead to advances in therapy. "Understanding HIV biologically is how you translate that to clinical innovation," he said. HIV replicates by infecting activated CD4 T cells, which then produce copies of the virus and eventually die of programmed cell death, or apoptosis. But if that were all, Greene said, they could easily be replaced by resting cells, which make up 95% of the targets encountered by the invading virus. Instead, the resting cells also die, in what he called a "vicious pathological cycle." In a series of experiments, he and colleagues show that the resting cells are the targets of "abortive infection," which cannot lead to fully formed HIV particles because the cells are not activated. Instead, fragments of HIV DNA are scattered around the cell, eventually attracting the attention of a sensor molecule, interferon-gamma-inducible protein 16, or IFI16. IFI16, the subject of the Science paper, initiates a process of cell death, mediated by the enzyme caspase 1 -- a molecule whose functions are the topic of the Nature paper. Apoptosis in productively HIV-infected T cells, Greene and colleagues found, is mediated by another enzyme, caspase 3. That form of cell death, Greene told MedPage Today, is a "very bland and silent process." In contrast, the cell death of an abortively infected T cell -- dubbed pyroptosis -- is a dramatic event, spilling the cell's contents and proinflammatory cytokines, including interleukin-1β. The result is inflammation, which draws more CD4 T cells to the area, where the HIV is waiting to repeat the process. "It's as if the cavalry rode in and then turned their rifles on themselves," Greene said. The good news is that blocking the activity of caspase 1 prevents the cell death and subsequent inflammation, at least in tissue experiments in the lab. Moreover, at least one caspase 1 inhibitor -- a drug known as VX-765 -- is available and has been found safe and effective in clinical trials, albeit in epilepsy and psoriasis. The researchers found that, in their tissue experiments, VX-765 effectively blocks caspase 1 activity, CD4 T cell death, and the release of interleukin-1β. Greene said he and colleagues are working with the drug's maker and are eager to move into human trials in HIV. If caspase 1 inhibitors prove as effective in the real world as in the lab, Greene said there is a range of possible uses. In the developing world, he noted there are some 16 million people with HIV who do not have access to triple-drug antiretroviral therapy. If a caspase 1 inhibitor were cheap, widely available, and easy to take, it might form a "sheltering place" -- slowing the progress of HIV while people waited for antiretroviral drugs. Even for people with access to drugs, treatment is sometimes problematic because of resistance or other issues and caspase 1 blockers might be of value for them, Greene said. Finally, there's evidence that inflammation drives the release of cytokines that in turn drive the proliferation of memory T cells. Memory T cells form the so-called reservoir of HIV that allows it to return whenever antiretroviral therapy is stopped. Caspase 1 inhibitors, he speculated, might be part of a cocktail of drugs that would lead to the "slow destruction" of the reservoir and the eventual clearance of HIV. Indeed, that might be the most promising part of the research in the long term, Daskalakis commented. "We know that the way to treat HIV is to give a full antiretroviral regimen," he said, and it's unlikely that caspase 1 inhibitors would replace that approach. But the resting and memory cells are "the untapped targets" of HIV therapeutics. "If a cell is replicating actively, we know how to shut down HIV in that cell," he said. "But what we don't know ... is how to focus on depleting" the resting and memory cells. A good understanding of that process might "really be the answer to drive the cure agenda," he said. Greene also noted that people with HIV -- even if it is well-controlled -- have chronic inflammation that is thought to drive higher rates of other forms of illness, such as cardiovascular disease. Blocking caspase 1 might reduce that inflammation and prevent some of the so-called diseases of aging that appear to strike HIV-positive people earlier than others, he argued. "If the biology leads us to a place where we can reduce inflammation," Daskalakis commented, "I think we're going to see better HIV outcomes with antiretrovirals.""

After 5 years, my VL is 14000, it came down from 15000, and my T cells are 850, pretty much what they were 6 months ago. I am not, never have been on meds. I consider myself very lucky, as I have known some people that got infected about the same time I was and they died already. I also have lost 3 friends while I have been here in Santiago.

Hell yes! I want 4 shirts, if possible. Size: medium T-Shirt Color: 2x black, 2x burgundy Front Graphic: 2x Raunchy Fuckers, 2x rawTOP Front Graphic Color: Up to you Rear Graphic: small biohazard, small rawTOP logo Rear Graphic Color: Up to you Thanks a lot!

They make a wonderful couple, I'd LOVE to see them again on camera, and of course, to do a nasty threesome! His Daddy was super hot.

Ah, I thought he was another one with a similar story who is about 28 (this is like the fourth case). Still, I was not an asshole when I was his age and there are a lot of really cool guys his age. No generalizations are needed.

RawTOP: That's not the only case when patients would be willing to take extra risks, but the current status quo won't let them make that choice. I have a few friends working in immune-system approaches for cancer. There's actually a lot of people willing to try anything for having a chance, yet, according to current regulations, patients HAVE to have access to the best available treatment at the same time. But chemo/radio wrecks your immune system completely. So, the proposed treatment can't be tried. We need a less paternalistic approach to these issues. I am a scientist, and I believe that people have the right to be informed and make choices.

Please, don't generalize about people. I am about the same age, and I think what he did is hideous and cowardly. So, chill out and direct complains to specific people, not to a whole group of us. You, older people, are supposed to be wise. Show it.

I guess I am a multi tasker. I love doing it, beyond hot. Not acrobatic at all.

I am almost 100% smooth (Native South American ancestors + European without a lot of hair, it seems), and I just can't get enough of rimming and fucking hairy asses

I have seen quite a bit of porn, and I haven't seen a lot of a top fisting two guys at the same time while fucking another. In real life, I have done it just a few times, it's difficult enough to find 2 fisting bottoms willing to share cock and hands. The first time, it was with my boyfriend, I fucked him while fisting the two guys. I was in Vancouver for 2 weeks for a conference, some pigs were anxious waiting for my cock and seed, so I rounded 4 of them and fuck them at the same time. Here are some pictures. https://www.breedingzone.com/album.php?albumid=4436 Have you done it at all? Interested in doing it?

I will be in Vancouver for a few days in mid-August Anybody interested in getting together? I like hairy, muscular, masculine men who are kinky submissive in bed. Poz and not on meds yet (low VL, lots of CD4 cells). HungLatinDom on BBRT, Estwald on ManHunt and AssPig. Any suggestions about places to visit? And, if anybody is willing to offer a couch for dick, I'll be more than happy to do it!

Estwald .

Yes, I host the parties at my apartment in Bellas Artes. Any pics or profiles where I can see you? Parties range from 6 to 20 guys, depends on the night...

Woof, Jake, that's really hot. I love to share piss when I am giving it to my bottom, don't swallow it all and give me back a bit. or spit it on me. and lick me afterwards. I'll lick the bottom if he gets sprayed. It's so good to see you here, BTW. I met you and your partner at a CumUnion party at Mack's Folsom prison in SF. I am that guy that fucked you both and asked to felch you when you were leaving, IIRC, I got five loads out of you.

Mononucleosis?

I guess I am not a decent guy. I would have nothing serious with a decent guy, either.