On-demand dosing as effective as daily dosing in first year of French PrEP study

[Veytoss]

http://www.aidsmap.com/On-demand-dosing-as-effective-as-daily-dosing-in-first-year-of-French-PrEP-study/page/3312313/

There have been no new HIV infections in the 1628 people taking part in a demonstration study of pre-exposure prophylaxis (PrEP) in France. Over half of participants chose to use on-demand dosing for PrEP, with the rest opting for daily dosing, but both have been equally effective, Jean-Michel Molina of the University of Paris Diderot told a press conference at the 22nd International AIDS Conference (AIDS 2018) in Amsterdam today.

Belgium also has a demonstration study offering either on-demand or daily PrEP, known as Be-PrEP-ared. The researchers have recruited 197 gay men and three transgender women. In contrast to France, over three-quarters selected daily dosing, whereas a quarter chose on-demand. Although the numbers are small, adherence appears to be poorer in the on-demand group (around 70% of sexual acts covered by PrEP).

Despite high levels of self-reported risk behaviour and a high incidence of sexually transmitted infections, there have been no HIV infections in the first 12 months of follow-up. These are interim results and the study continues.

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AFAIK "on demand" here means the classic regimen 2 tabs 24 hours before and 1 after 24 hours, but correct me if I'm wrong.
 

Edited August 21, 2018 by Veytoss

[Leather69]

Hi Veytoss

PeEP event dosing is 2 tablets at least 2 hours and not more than 24 hours before sex.. then after sex 1  24hrs(22-26 hrs) and another 48 hrs (46-50) after sex. Taking multiple loads over several days ..take 2 before then one  per day and after 1 a day for another two days.  

Edited August 22, 2018 by Leather69