rawfuckr Posted Wednesday at 03:59 AM Report Share Posted Wednesday at 03:59 AM [think before following links] https://www.drugtopics.com/view/lenacapavir-for-prep-demonstrates-strong-efficacy-in-second-phase-3-trial Had better hopes for lenacapavir in MSM group but 2 infections happened on the drug arm and adherence can't be questioned here (it's an injectable twice a year). Seems daily truvada/descovy is still closer to 100% than the injectables (apretude and lenacapavir) with good adherence. Link to comment Share on other sites More sharing options...
greo Posted Wednesday at 07:30 AM Report Share Posted Wednesday at 07:30 AM 3 hours ago, rawfuckr said: [think before following links] [think before following links] https://www.drugtopics.com/view/lenacapavir-for-prep-demonstrates-strong-efficacy-in-second-phase-3-trial Had better hopes for lenacapavir in MSM group but 2 infections happened on the drug arm and adherence can't be questioned here (it's an injectable twice a year). Seems daily truvada/descovy is still closer to 100% than the injectables (apretude and lenacapavir) with good adherence. It's not though. They showed a 96% risk reduction with the injectable. Truvada is more like 80-90% even with high (>80%) adherence (also see [think before following links] https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00106-2/fulltext where the were 73 PrEP failures, they saw 93% risk reduction in their highest adherence group). Recent review ([think before following links] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096492/) still shows an infection rate of 9 per 1000 per person year with Truvada and high adherence. Link to comment Share on other sites More sharing options...
rawfuckr Posted Wednesday at 11:51 AM Author Report Share Posted Wednesday at 11:51 AM I'm talking about daily real adherence. That study adds to the high adherence group people who were skipping doses here and there. With daily adherence truvada is north of 99% clearly. So if you are capable of taking a pill and a day you'll still be ahead efficacy wise from the injectables. Link to comment Share on other sites More sharing options...
greo Posted Thursday at 07:25 PM Report Share Posted Thursday at 07:25 PM On 9/25/2024 at 1:51 PM, rawfuckr said: With daily adherence truvada is north of 99% clearly. So if you are capable of taking a pill and a day you'll still be ahead efficacy wise from the injectables. Evidence: I pulled a number out of my arse? 1 Link to comment Share on other sites More sharing options...
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