Lenacapavir not quite 100% in MSM

[rawfuckr]

[think before following links] https://www.drugtopics.com/view/lenacapavir-for-prep-demonstrates-strong-efficacy-in-second-phase-3-trial

Had better hopes for lenacapavir in MSM group but 2 infections happened on the drug arm and adherence can't be questioned here (it's an injectable twice a year). 

Seems daily truvada/descovy is still closer to 100% than the injectables (apretude and lenacapavir) with good adherence. 

[greo]

3 hours ago, rawfuckr said:

[think before following links] [think before following links] https://www.drugtopics.com/view/lenacapavir-for-prep-demonstrates-strong-efficacy-in-second-phase-3-trial

Had better hopes for lenacapavir in MSM group but 2 infections happened on the drug arm and adherence can't be questioned here (it's an injectable twice a year). 

Seems daily truvada/descovy is still closer to 100% than the injectables (apretude and lenacapavir) with good adherence. 

It's not though. They showed a 96% risk reduction with the injectable. Truvada is more like 80-90% even with high (>80%) adherence (also see [think before following links] https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(22)00106-2/fulltext where the were 73 PrEP failures, they saw 93% risk reduction in their highest adherence group).

Recent review ([think before following links] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096492/) still shows an infection rate of 9 per 1000 per person year with Truvada and high adherence.

[rawfuckr]

I'm talking about daily real adherence.  That study adds to the high adherence group people who were skipping doses here and there. 

With daily adherence truvada is north of 99% clearly. So if you are capable of taking a pill and a day you'll still be ahead efficacy wise from the injectables. 

[greo]

On 9/25/2024 at 1:51 PM, rawfuckr said:

With daily adherence truvada is north of 99% clearly. So if you are capable of taking a pill and a day you'll still be ahead efficacy wise from the injectables. 

Evidence: I pulled a number out of my arse?