I believe repeated aggressive deep cleaning will have long term consequences. I had a boyfriend for a two-year period who'd fuck me three or four times a week. Before getting together, I'd always deep clean in anticipation, just in case we might screw. Over time, I developed internal hemorrhoids, chronic soreness in the muscles around the rectum, and low motility (IBS with constipation). I suspect the bacterial balances are way out of whack, but I won't go into the details of that. I don't bottom so much nowadays, so I clean out only a couple times a month, and I'm slowly getting better. But the motility problem persists.
These problems are not really addressed in medical journals, so GI docters think it's some kind of IBS when they rule everything else out. I tried to discuss this with my (gay) doctor, but the medical community just haven't gotten around to studying "whore-ass fatigue syndrome."