Moderator: A tangential discussion from the Doxy-PEP topic, on another threat to our health and happiness:
The issue becomes CA-MRSA and it will become a large issue. In the USA/CA/MX regions MRSA is already almost always fully resistant to not only all methicillin, it is resistant to Clindamycin and shows Tetracyclines are becoming much, much weaker on it as a whole if not entirely resistant. That leaves the only treatments as Bactrim (which is not good at treating SSTIs as it has a hard time going into those areas), Vancomycin which is only IV and will destroy your kidneys if used to often anyways, plus it has a very slow effect, or Linezolid/Zyvox which is a new last line Antibiotic and is almost $1000 a dose AND an MAOI and Bone Marrow suppressant. . That can lead to low blood cell, platelet and plasma levels. To be truly effective, as it is not bactericidal but bacteriostatic, it needs Rifampin single does put with it and Rifampin is not a drug you want to take unless you're fond of Orange eyes, urine and saliva, all bodily fluids turn orange and the kicker is resistance emerges RAPIDLY to Rifampin
We already have Bactrim and Vanco resistant a strains and once you get that it's basically amputation of infected limb or thoughts and prayers. What really needs to be done is finding a whole new class of antibiotics that function in a new way entirely. MGO may be a start as it weakens a cell so that it dies in division and doesn't allow it to pass on its genetic information but it's very hard to synthesize or stabilize. Tetrabactins are being explored but we don't know the long term effects nor their true method of action. It's great that things are being looked into but it's honestly just trading time in the future for more time today and until something dramatically changes in pharmaceuticals or prescribing, prophylactic antibiotics are not something I think we should be using especially with ones already showing a growing resistance to very, very common (20%-30% of all people colonized by MRSA according to recent data) superbugs AND making the even more deadly and dangerous Gram Negative bacteria (Microbacter and Pseudomonas) able to become resistant and flourish in a depleted microbiome.