Can you get pozed if you don't take prep everyday?

[Safer]

I have prep but I don't hookup much so I tend to take my prep inconsistently, it also makes me nauseous sometimes when i take it right after i had a few. Like when I first got it I took it everyday and then stopped for about three weeks, then I took it for two days in a row before hooking up with a guy (I was the top) then I took another dose the next day and the day afterward and stopped again, that was in late March.

Then in mid May I took a box test which came back Neg. I haven't hooked up or tested since then but could I still be poz?

[Pozzible]

I’ve gone off PrEP myself because I just haven’t been having much sex. What I’m doing is the 2-1-1 PrEP. As I understand it - and I haven’t talked to my doc about it yet - is that you take 2 Truvada pills 2 hours before sex. And then take one pill 24 hours later and the fourth the next day at the same time. My understanding is that Descovy may not work for 2-1-1. I’m sure there are others on here with a more definitive answer. 

[viking8x6]

With daily PrEP dosing, the side effects often lessen or disappear after taking it regularly for 2-4 weeks, as your body adjusts to it. Descovy is reported to have fewer side effects. If you don't take it consistently, it is possible to seroconvert, and this is a bad idea because that can result in the virus becoming resistant to the drugs in PrEP. It is better to use the "on demand" dosing described by @Pozzible, or to use the new bimonthly injectable PrEP.

@Pozzible's explanation of "on demand" PrEP (2-1-1) is exactly right. The first dose must be taken between 2 and 24 hours before sex, and the other 2 doses at 24 hour intervals after that.

[Cutedelicategay]

This is a big discussion within the medical community as told to me by my ID specialist - Prep fatigue. Prep is a medical miracle for the community and a couple of breakthrough cases are based on inconsistent use. A Prep resistant strain would harm a lot of people who religious take Prep to stay negative. TBH it is not a joke to mess around with medication doses. Either take it everyday or on demand or ask for Prep injection. If Truvada is an issue switch to Descvoy. If at all just stop the medicine and take chances but do not ruin it for others who want to take care of their health and the health of others around them. Such discussions really scare a lot of men that I know. 

[Safer]

1 hour ago, viking8x6 said:

With daily PrEP dosing, the side effects often lessen or disappear after taking it regularly for 2-4 weeks, as your body adjusts to it. Descovy is reported to have fewer side effects. If you don't take it consistently, it is possible to seroconvert, and this is a bad idea because that can result in the virus becoming resistant to the drugs in PrEP. It is better to use the "on demand" dosing described by @Pozzible, or to use the new bimonthly injectable PrEP.

@Pozzible's explanation of "on demand" PrEP (2-1-1) is exactly right. The first dose must be taken between 2 and 24 hours before sex, and the other 2 doses at 24 hour intervals after that.

I am on Descovy. Does inconsistent use atleast provide some protection, like does what i describe sound low risk? And is my result from May likely to be accurate?

[viking8x6]

Inconsistent use in the exact way you described would be likely to provide some protection (although no one knows how much, because it would be unethical to do a controlled study of that).

But honestly, even without any PrEP at all, what you describe sounds fairly low risk. It's a single encounter with you as the top, so your chances of getting HIV would be less than 1 in 100 even if the other guy were poz and not on meds - which itself is quite unlikely.

Yes, your result from May is very likely to be accurate.