Depends on the regimen you get put on. My partner and I are on one pill a day. They do a viral dna test to see what medicine you're most compatible with. Most people can handle the one a day pill, but if the virus starts mutating or your body reacts negatively to the medicine, then it changes.
The first 3 days are like tripping balls. Almost a lot like doing shrooms or LSA. I got visuals when I went on Atripla in 2008 (been diagnosed since 2003, and on the same meds since then). After the first few days, you get used to it, and just like you said for your other medicine, you get used to it and it becomes part of your routine.
For some reason, though, it does cause a heat flash in me and my partner about 30 mins after we take it.