Side Effects of PrEP

[Guest JizzDumpWI]

bearbandit, some months back, maybe even a year ago, you mentioned a reformulation coming for tenofovir. Any update on that? When I brought this up with my ID doc last week he had not heard of that....

[rawpisspig]

Can someone tell me the difference between Prep and PEP with regard to medicines used etc. Thanks in advance guys.

[bearbandit]

 

bearbandit, some months back, maybe even a year ago, you mentioned a reformulation coming for tenofovir. Any update on that? When I brought this up with my ID doc last week he had not heard of that....

 

I can't find anything since this time last year at which point tenofovir alafenamide fumarate was in phase 3 trial. All the signs in the UK were that the new version would be available pretty much as stocks of the old formulation ran out. Disappointing news...

[bearbandit]

Can someone tell me the difference between Prep and PEP with regard to medicines used etc. Thanks in advance guys.

PrEP is one pill a day (truvada, which is made up of tenofovir and FTC, so it's a double drug).

PEP is only effective if started within seventy-two hours of possible exposure, ie before HIV has a chance to establish itself. It's a standard combination as taken by PwHIV, using truvada as the backbone to which is added another drug. Raltegravir is becoming more and more popular as the third drug, despite the fact that it's a twice a day drug, the reason being that it's got a deeper penetration into places where HIV hangs out. There are signs that the integrase inhibitors (of which raltegravir is one) are going to be as revolutionary as the protease inhibitors were in the late nineties onwards.

[Poz1956]

At the moment there is only one combination approved for PrEP.  Truvada which is two NRTI drugs once a day.

 

PEP guidelines differ from place to place.  I've read them for five different jurisdictions.  Drug and dossage reccomendations are not consistant among any of them.  There is leeway for prescribing physician to make choices about the level of exposure risk, and how hard to hit the bug.

 

At the bottom end of the scale is a two NRTI dug, once a day regime.  Truvada would be a prime candidate for that.

 

In the middle would the three drug once a day (same as a Pozzie), or two NNRTI twice a day.

 

At the top end of the "Hit it Hard" school of thought, I've seen a four drug reccomendation (2 NRTI & 2 Protease Inhibitor), with three of them taken twice daily.