greo Posted July 1 Report Posted July 1 3 hours ago, Tiboer said: I don’t believe Descovy has been studied for Prep on Demand like Truvada has been. Theoretically it should work but Truvada is the one proven to. European AIDS Clinical Society (EACS) Guidelines 2024 ・The standard “2+1+1” regimen for on-demand PrEP (2 pills taken 2–24 hours before sex, 1 pill 24 hours later, and 1 pill 48 hours later) is strongly recommended based on robust scientific evidence and has been shown to be highly effective for MSM (men who have sex with men). ・Descovy (F/TAF) can be considered for on-demand PrEP. Pharmacokinetic (PK) studies suggest some effectiveness, and it may be suitable for individuals who need to consider kidney function and bone marrow health. Quote
DevilDawg Posted 3 hours ago Report Posted 3 hours ago On 6/10/2024 at 10:38 AM, blackrobe said: I started PrEP and had no side effects. Except I got to take a lot of bare dick and seed without fretting about HIV at all. I'd consider trying the daily dosing to see if ii's a matter of your body being able to adjust/adapt. I agree with this post. I have been in multiple Leather Clubs, most all of which put major monies into stopping the mass deaths during the peak tide of AIDS. One group of 4 clubs pooled their resources and funded the simple Gay Men's VD Clinic at the Methodist Church in Georgetown - Washington DC into becoming the bright star of Elizabeth Tailor - The Whitman-Walker Clinic. When I was looking into PrEP, and then PEP after starting and stopping PrEP I received the same synchronized advice between the Veterans Administration Infections Disease (ID) clinic of the DC VA MC, Georgetown Medical, ACT Toronto, and others. At the time, there was a lot of noise about the European Dosing Model which is close to the 2-1-1 model cited. I also supported the outstanding efforts of the Aids Council Toronto (ACT). As Bernard one of the VA Experts explained to my technical geek mind DOSING plus and minus is an exacting measurement set based on tested and lab trial methodologies. For instance, I am prone to uric crystals better known as Gout. If I take the prescribed dose of ONE Colchicine micro tablet - existing crystals fade and if I am not symptomatic, they are prevented from appearing in any large amount (and I drink a LOT). If I take MORE than one Tab a Day, I get diarrhea. Likewise, when I was on different versions of PrEP, and forgot and took two tabs in a day, I would get diarrhea. I was advised just how stupid this was even through he called me an idiot (politely). You see, excess medication is set for a reason. Taking more only loads up your kidneys and places your health at more risk than not taking anything. Look it up and do the math. If you fill your car gas tank with 15 gallons, and hose and additional 15 of gallons into a ditch you are 'throwing away' 15 gallons, breaking the law, harming the environment, etc. If you take 2 pills where the dosage is calibrated for (1) in a 24 hour period, the waste is something your kidneys and liver have to deal with. Too Much is TOXIC, Too Little is ineffective. Take a lesson from Goldilocks and do not overthink medical dosing beyond the FDA, and your National Health recommendations. If you have a quack doc or nonDOC like Kennedy who is giving you advice contrary to the listed dosing just remember (please) you cannot sue them if you are dead. Lastly, try moving your 1 pill PrEP dose to bedtime. Any watery poop (I used to refer to them as pooping Tribbles) would be passed in a normal Morning bowel Movement. OR - If you are a slut like myself who bends over when opportunity presents itself at any Glory Hole that interests you, you can avoid all the issues of loose poop and trying to remember the last time you popped a PrEP dose, I am now on Injectable Prep and get 6 shots a year with periodic liver and kidney monitoring. If any of this proves useful, It is My Pleasure to Serve and Protect Your Anus....... - Quote
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