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I knew this day would come as my brother is asking me about the effects of GHB & Meth when having sex.
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For whatever it's worth, take a look at drugs-forum.com; the website covers a vast assortment of substances, and the general theme is harm reduction. And tweaker.org is excellent about meth use, sex and meth, etc. Your brother might think you're holding information -- or him -- back. Pointing him in the direction of these two websites might help. And in any event, good luck...
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I have shown him those 2 sites already and thanks.