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Posted

i think bootman is correct. drug resistant may mean your prep etc will fail. maybe not. it is just another type of american roulette. if you are willing to take a chance...also, of course, there is a difference between hvl and drug resistant, though the two can combine.   caveat fucked

Posted
11 hours ago, BaphometNocturne said:

There is this misconception that people with high VL's can transmit a resistant strain to undetectable's. Whether you are undetectable or on PrEP, you are protected against his strain. He cannot infect you. Have asked this question to both my specialist and to my pharmacist. I can take all the high VL's I want and I am still protected against them because I am undetectable and I take my medication.

The only thing I can think of is that if you have one of the two species of HIV (HIV-1 and HIV-2), you could catch the other one or another strain or something.

Your specialist and pharmacist were probably right to say you don't have to worry. You're on meds so this fights the HIV virus. This gives you a strong protection against re-infection as well.
And your bloodwork is monitored regularly so even if something changes, they can put you on another combination of med's to keep you undetectable or get you undetectable again.

Posted
7 hours ago, BaphometNocturne said:

If you are protected, you are protected. It does not matter if that person has a rare strain that is resistant to those medications. That simply means that those medications dont work for them. It does not mean that he can transfer that strain to people that are protected because theyre on ARV's or on PrEP.

This means that if the person has a rare strain that is resistant to both of the the med's that make up PrEP, that particularly type of PrEP can't protect against this strain, or at least it's protection is lower. Or am I missing something? 

So I think BootmanLA has got a good point there.

But like I just said I don't think this is applicable to your situation as you're already HIV-positive. 
Good for you listening to your doctor and pharmacist, taking your meds and great you are Undetectable. That way your health stays ok and you can't infect someone else.
Yay.

Posted (edited)

 

This is from aidsmap, which does a good job i think providing evidence based information about HIV/aids.  One of the things that causes lots of confusion in healthcare is authority and/or speculative vs evidence based information on healthcare topics. I.e., people, even legitimate lettered scientists, will draw conclusions or speculate based on their expertise (or lack of the same) instead of study based evidence. That kind of speculation is not without value, it's how theories get traction, theories that will hopefully be tested in quality, large double blind randomized studies that result in evidence, and then hopefully those studies get independently replicated by other scientists and it all gets published in reputable scientific journals where the entire population of scientists can scrutinize the results.  Scientific evidence is not immutable  'truth', it's the best we know right now. The only place one can get "immutable truth" is at church (that's tongue in cheek guys).  Meanwhile, evidence based is considered by most scientists to be the gold standard. 

"Key points

HIV drug resistance can only arise in PrEP users if they take PrEP when they already have HIV.

This is why you should get tested for HIV before you start PrEP, and keep testing regularly.

If you take PrEP as directed, you won’t catch HIV, you won’t develop drug resistance, and PrEP will continue to work.

A study has found that, in a largely gay HIV-positive population with adequate treatment levels, at most one in 500 cases of HIV infection featured a virus that might possibly be resistant to PrEP.

There are differing views on how much PrEP use will add to the burden of HIV drug resistance. But its contribution will be small, compared to the impact of lack of support for adherence and for regular viral load testing in people living with HIV."

[think before following links] [think before following links] [think before following links] https://www.aidsmap.com/about-hiv/prep-and-drug-resistance

Edited by tallslenderguy
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Posted
9 hours ago, chibtm2breed said:

No that is NOT TRUE!!!! That is for SURE. BootmanLA is correct NOT what you think or did hear from your local Doctor. YOU really should google the scientific data for yourself. Although I think it's much more the case for a PrEP person with only 2 meds and I think re-infection with a stronger virus from what I've seen in studies is rare.

Where did you get your medical degree?

  • Downvote 2
Posted
18 hours ago, BootmanLA said:

That's simply not true. You're making the assumption that a drug-resistant strain will still be stopped by PrEP (or by being undetectable). The entire point about drug-resistant strains is that the drugs to which they're resistant won't affect that strain. That means, in turn: the person with that strain can't be treated with that drug, AND anyone who's taking a form of PrEP or being treated for HIV with medications that include that resistant drug is at potential risk for infection. That's not to say that such a person is going to infect everyone he has sex with. It's to say that protection is not completely assured.

PrEP is a powerful tool, but it's not an absolute, 100%, iron-clad guarantee against infection. It's pretty damned close, but if PrEP (in a particular case) consists of drugs A and B, and Joe has a strain of HIV that has become resistant to treatment by A and B, then that PrEP may not protect people with whom he has sex.

Mind you, there aren't very many strains of HIV that are drug resistant and even fewer that are resistant to more than one medication. That's why PrEP will continue to be effective for MOST people even in these cases, and why undetectable people (whose medications typically consist of at least three components) are even more likely to be protected from a super-infection. But blanket statements of "won't transmit to you" and the like don't belong in discussions of risk. 

I suspect what your specialist said and meant was that a guy who simply has a high VL can't harm you as long as you remain undetectable - which is, broadly speaking, true. It's not like him having a high VL is going to be too much for your treatment regime to fight off. But if that high VL is drug-resistant to one or more of the meds you're using in treatment, the calculus changes. It may be that the other drugs in your treatment regime (since there are typically 3 or 4 in each pill) will be sufficient to keep you undetectable even if one of the three is rendered ineffective because you've acquired a strain resistant to one of your meds. But that's not a guarantee.

What's keeping this from being a big problem, for now, is that drug-resistant strains are still relatively uncommon in this country. 

OK so even if drug resistant strains are relatively uncommon here, can his strain become drug resistant if he takes breaks from his medicine for weeks and months at a time like he currently is doing? That's my only concern as opposed to someone who never went on biktarvy.

Posted
16 hours ago, TonyBear said:

OK so even if drug resistant strains are relatively uncommon here, can his strain become drug resistant if he takes breaks from his medicine for weeks and months at a time like he currently is doing? That's my only concern as opposed to someone who never went on biktarvy.

 

Either listen - or rather the guy thinking about taking a break from his meds should listen - to his (or your own) doctor.
Why not go to a doctor, explain the situation and ask them in stead of on this website where you don't even know who the guy is, answering your question?

Sometimes I feel it's dangerous we on this forum are talking amongst ourselves like we are doctors and know everything just because we have practical experience.

Simple questions lead to simple and oversimplified answers IMO.... and people who are overly sure about what they think is the truth might sound convincing but that means nothing.
Like with in most things in life, we get no 100 % guarantees mate. That's life.

 

This on the other hand is a very goed suggestion, if you want to learn more I'd invite you to watch this video:

On 10/19/2021 at 10:46 AM, Kimberley said:

It's ok if you can't or won't then it's even more so a good reason to talk to a doctor and not get your info from a forum like this one.
It's a wise man who knows what he does not know. And it's a confident man who trusts (medical professionals in this case). 

Peace. 

Posted
2 hours ago, BareLover666 said:

 

Either listen - or rather the guy thinking about taking a break from his meds should listen - to his (or your own) doctor.
Why not go to a doctor, explain the situation and ask them in stead of on this website where you don't even know who the guy is, answering your question?

Sometimes I feel it's dangerous we on this forum are talking amongst ourselves like we are doctors and know everything just because we have practical experience.

Simple questions lead to simple and oversimplified answers IMO.... and people who are overly sure about what they think is the truth might sound convincing but that means nothing.
Like with in most things in life, we get no 100 % guarantees mate. That's life.

 

This on the other hand is a very goed suggestion, if you want to learn more I'd invite you to watch this video:

It's ok if you can't or won't then it's even more so a good reason to talk to a doctor and not get your info from a forum like this one.
It's a wise man who knows what he does not know. And it's a confident man who trusts (medical professionals in this case). 

Peace. 

Well, I asked the online doctor who prescribed me prep and he gave a very simplified answer, suggesting that as long as I am taking my medicine as directed I should be fine, ignoring the other factirs I mentioned. So, I'm guessing from all the responses I've gathered and the lack of info I'm finding about it, that if what I'm thinking of does happen, it isn't common enough for it to be a very known or worrisome issue. For now, I've just put off getting with the guy until he gets back on his meds again. I did watch the video and it seemed worrisome, however, what the speaker neglected to mention was just how fast that sort of viral replication took in order to reach that resistant state. I didn't have a frame of reference as to whether that was over a week or two or over 10 years. That makes a big diference when talking about viral replication. The guy told me he had over 800k viral load after only stopping his meds like a month and a half ago, and he told me it could take him up to 3 months for him to get undetectable again, so I'm not sure what that means in terms of his HIV mutation and replication. I honestly think I'd probably be fine at this rate, but considering I have so many sexual partners, it's probably best to just sit this one out for now.

Posted
2 hours ago, TonyBear said:

Well, I asked the online doctor who prescribed me prep and he gave a very simplified answer, suggesting that as long as I am taking my medicine as directed I should be fine, ignoring the other factirs I mentioned.

Sounds like good advice.

Perhaps the online doctor didn't want to give out information that wouldn't help you to stay neg, based on something that someone told you that either is or isn't true.
Using condoms, taking PrEP (or both of these) and abstinence from sex are the only and best options to not contract HIV.

It occurred to me your online doctor may be reluctant to hand out information that basically could be perverted into a how-to-guide of what to do, in order to achieve med-resistance if some idiot got his hands on it.

 

2 hours ago, TonyBear said:

I honestly think I'd probably be fine at this rate (...) it's probably best to just sit this one out for now.

Good choice, and it's your choice.

Posted

well i'd love him. if i knew his sniffie I'd hit him up now. (mmmm. could you give him my handle!)  and i am not on prep but still neg

Posted
1 minute ago, nastysubbbbottom said:

well i'd love him. if i knew his sniffie I'd hit him up now. (mmmm. could you give him my handle!)  and i am not on prep but still neg

He and I are both in the Birmingham, Alabama area, so a bit far from the location on your profile, sorry.

Posted
1 minute ago, TonyBear said:

He and I are both in the Birmingham, Alabama area, so a bit far from the location on your profile, sorry.

actually i travel all over so it would still be possible but i also get being reluctant to share such info. in any case good luck with the encounter if/when it happens.

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