Fast forward five years... And the doc's point is worth considering. TaSP is quite effective all by itself. If one mostly bareback's Undetectable poz guys one's risk of HIV is virtually nil. But indeed even still five years later it is the other STI's which are dominating the infectious disease guys. And treatments for those more challenging. And while it is possible mRNA solutions might be combatively near at hand for those; the things it is this fairly continuous set of STI's that my local clinic treats me for much more often than 10 years ago I was on PrEP until I retired and started Medicare. It is cost prohibitive for me to buy a drug plan that includes PrEP; whereas their are still no cost HIV treatment available (at least by me). I honestly don't much care since I am on similar medication either way; and long term prognosis is acceptable either way. So PrEP for my particular demographic is too expensive.