ARV and Coronavirus

[Asiansluttypig]

Dear Folks, 

I want to discuss interesting topic about corona virus and ARV, 

If you following news from begininf, you might hear that the doctors using ARV to fight Coronavirus. 

Since it was more like trial experiments which were success, it open possibility that ARV effectively fight Corona Virus. 

So, my question is, is there any member who HIV positive live in country or city with high case Coronavirus but you atill fine? 

Or do you have any friend who is HIV positif and under medication hospitalized because corona? 

Is there any Prep user until now or do you know someone who use prep get sick because of Coronavirus? 

Lets. Discuss

[think before following links] https://www.scientificamerican.com/article/to-fight-coronavirus-outbreak-doctors-deploy-drugs-targeting-hiv-malaria-and-ebola/

 

 

[lower_bucks_bottom]

Looks like it does not work as a treatment

[think before following links] https://www.sciencenews.org/article/coronavirus-pandemic-hiv-drugs-do-not-work-treatment-clinical-trial

No word about it acting as a prophylaxis 

[viking8x6]

There is very little reason to think that anti-HIV medications would be likely to work against Covid-19 (or any other coronaviruses), because they are in a different family of viruses that have a different life cycle. In HIV, the RNA of the infecting virus is transcribed to DNA (by a virus enzyme) and inserted into the host's DNA, and only later is that DNA copied out into RNA for new viruses (by the host's enzymes). In Coronaviruses, the RNA of the infecting virus is copied directly into the new virus RNA (by the virus's enzymes). So in one case the virus is making DNA and in the other it is making RNA, and the two enzymes are consequently very different and unlikely to be blocked by the same drug molecule.

Worth a try, but unlikely to be of too much use.

In better news, this explanation does *NOT* apply to drugs against Ebola and Influenza (e.g. Tamiflu), because both of those viruses use the same replication strategy described above for coronaviruses. So they would be much more likely to have effectiveness against Covid-19.