advance Potential HIV cure approved for a human clinical trial

[POZSado]

Human clinical trials approved in the DC area on a possible cure for HIV.

Interesting to see the advancement of the research made in the treatment of HIV.  While this might not be the final solution to curing HIV, it's definitely a large step forward.

Read the article here:

Potential HIV cure approved for a human clinical trial, LGBTQ Nation

[sjthick8inches]

@POZSado Thanks for the post. Not sure why, but I couldn't get a link from your post. Here is another try at the link:

 

[think before following links] [think before following links] https://www.lgbtqnation.com/2020/08/potential-hiv-cure-approved-human-clinical-trial/

 

Edited August 23, 2020 by sjthick8inches
Add acknowledgement.

[POZSado]

Thanks, it appears embedding doesn't work...

[BootmanLA]

3 hours ago, POZSado said:

Thanks, it appears embedding doesn't work...

It does not. This has been widely discussed elsewhere in the forum; because of links to spam sites, etc., you can post the URL to a site, but it won't be clickable, and if you try to insert an embedded link, you only get the title, not the URL.

[Jellyfish]

Curing never means no re infect

[funpozbottom]

On 12/30/2024 at 1:57 PM, Jellyfish said:

Curing never means no re infect

If I'm understanding the study, it involves modifying a person's own T-cells so they withstand an attack by the HIV virus. Since the goal is to repair the immune system and improve the immune response, the body could, in theory, rid itself of HIV and fight off any new exposures. If that happens, it actually would be a cure. Unfortunately, the study hasn't gotten very far -- it is still in phase 1 and a long way away from an actual treatment.  

[fuckyouraw777]

What will be very interesting is what the various communities here would do in the face of a freely available "cure"...

[piglooking4pigs]

If you're interested in learning more, you can follow along on the most recent developments at clinicaltrials[dot]gov and at the company's (American Gene Technologies) website at americangene[dot]com.

The link to view the clinical trial data is [think before following links] https://clinicaltrials.gov/search?cond=hiv&term=agt-103. Here you can see the sequence of trials that the company is sponsoring to test its treatment.  Thus far, the trials are taking place in Washington, DC (at Georgetown University Hospital and Washington Hospital Center).  The study includes only 7 trial participants who were included by invitation only. 

The trials are still in Phase 1.  As many of you know, there are generally 3 phases to clinical trials.  Phase I usually tests the safety of the treatment and is conducted on a small number of people, hence the 7 here.  To date, it seems that the 7 trial participants were infused with the edited T-cells (Phase Ia).  Phase 1b is underway in which the 7 participants will stop their ARV therapy and be closely monitored for adverse effects and for HIV rebound.  According to clinicaltrials, Phase 1b is expected to be completed in July 2025 -- so in a few months, although we will not have the results of this phase for some time after the trials phase closes.

If the trial proceeds to Phase 2, a larger pool of people at various sites throughout the country will be able to participate and finally in Phase 3 an even larger number.  Hopefully, the trials will be structured to include a diverse participant pool, including women and trans individuals. 

Given that Phase 1 may conclude this July, it is still a while away from knowing how effective this treatment might be (Phase 3), but the FDA has been known to stop a trial if the results are so positive that it feels a greater number of people will benefit without having to wait for the trial to end.  It's rare, but has happened.

The company also maintains an HIV clinical trial timeline at this site: [think before following links] https://www.americangene.com/milestones/hiv-cure-countdown/

 

[Chrisjoci]

I really hope 1 day there is a cure. I'm still negative and I hope to stay that way. Thanks for sharing this information.