Usccocksucker

Definitely keep it going!

There aren’t a ton of us, so figured it would be good to know other locals 33 yo wm neg bttm (though top on occasion)

Anyone been to the Ball Buster parties? If so, how was it?

Great narrative style! Please keep writing!

Hey guys, I’m moving to the NYC metro area and I’m starting to look for a place to live. The NYC area is obviously huge, and the housing market is brutal. I’m hoping you guys who have been here for a while could give me some tips on what to consider when choosing an apartment. Particularly one that’s good for taking lots of loads. Unfortunately my work is up in Westchester County so the commute would be a bit tough unless I lived accessible to the Metro North. Any recommendations on neighborhoods, factors to consider, and any other advice when looking for an apartment? I definitely plan on having a place to myself. Related question: can a bottom get good dick in Yonkers or White Plains if he lived near the metro? Thanks in advance!

The most boring hook up for me has been when the other guy takes too much G and passes out. That’s literally just the end. He would’ve been okay with me fucking him, but I was in chastity, so I couldn’t even do that. I just left. ?‍♂️

I wouldn’t go quite that far. This is still pre-exposure prophylaxis because you need to take the first double dose prior to the exposure. The subsequent doses are to maintain antiretroviral concentrations during the period of time that the virus would be capable of replicating. I would not recommend waiting until after an exposure to take only Truvada. After an exposure, there is really only evidence right now to support full-on PEP.

Pharmacist here, and I second the nurse. There was a trial called the IPERGAY trial that looked at the use of “on demand” PrEP. “On demand” meaning that PrEP was only taken around times of intercourse. Patients would take their first (double) dose 2-24 hours prior to sex and would only continue (with single doses) for two days after sex. Despite the short time on the drug, this still resulted in an 86% drop in seroconversion. A week of regular daily dosing is quite sufficient.

Very hot! I’ve never been on a St. Andrews Cross, but definitely want to. I highly encourage you to go to your local bathhouse. It’s a fun time! Keep your expectations reasonable — you might not hop in the sling on your first time there. But once you get comfortable there, it’s a great place to be to get lots of stranger cum ?

Very hot!

Hey guys, I had a ton of fun at MAL this year and enjoyed shopping at all the vendor booths. It got me to thinking — what are some of everyone’s favorite (non-chemical) gear, toys, devices, etc. to enhance your play sessions? Would love some recommendations from some other pigs!

That’s fucking disgusting! ...so of course I have! ??

Methemoglobinemia is a well-known adverse effect of nitrites/nitrates and may be the cause of the cyanotic fingers you’re experiencing. It can be dangerous at high levels of methemoglobin, as the methemoglobin (an altered form of hemoglobin formed by the nitrates) is much less efficient at delivering oxygen to peripheral tissues. This is an effect that is mechanistically unrelated to hypotension and the vasodilatory effects of the nitrates, and the onset occurs after the vasodilatory effects. On the extreme end of things, patients with methemoglobinemia can become hypoxic and can develop CNS depression and/or a metabolic/lactic acidosis. This generally occurs with very heavy popper usage. The cyanotic symptoms described sound consistent with mild methemoglobinemia, but it’s hard to tell without a work up. Hope this helps!

Nooooo. What a loss

It’s because it’s not said to be effective until it’s shown to be effective in clinical trial for that specific use. It helps to understand the chemistry a bit. Tenofovir alafenamide (TAF) is slightly different from tenofovir disoproxil fumarate (TDF). Both of them have tenofovir, the main active part, bound to another molecule. But that other molecule is different in both cases. Why is tenofovir bound to another molecule anyway? Well, tenofovir by itself doesn’t get absorbed well. By adding these extra bits to the tenofovir molecule, the absorption of tenofovir is increased. And when TDF and TAF get inside the cells, they both get converted to the active form of plain, old tenofovir. We call TAF and TDF “prodrugs” — drugs that aren’t active until they’re converted in the body to their active form. Okay, so we’ve established that tenofovir doesn’t get absorbed as well as TDF and TAF, so that’s your first clue that, despite them all having the same main active bit, they don’t all have the same efficacy and safety. If the drug can’t get to where it needs to work, it’s not going to be very effective. Now what’s the difference between TAF and TDF? Compared to TDF, TAF prefers to go into cells instead of staying in your plasma. This is potentially good for a couple of reasons. (1) That’s where the action happens — more drug in the cells can be good because the step in the viral lifecycle that tenofovir interferes with happens inside of cells. (2) Tenofovir can be tough on the kidneys and can have effects on bone mineral density. If the tenofovir is in the cell as opposed to in the plasma, there is less chance for the tenofovir to hurt your kidneys or bones. Clinical trials in the setting of HIV treatment showed that TAF was just as good at achieving viral control as TDF (showing efficacy), but it also had fewer adverse effects (showing this improved safety). So why can’t we use TAF for PrEP if it’s so great? Well, because there isn’t enough data on it’s use in prevention. In prevention, you’re blocking the virus from being able to establish an infection, so you want to be sure that TAF gets to the specific tissues (genital tissues/mucosal tissues) where HIV infection starts as good or better than TDF. This is the part that’s not as clear yet, though there are studies being done that look promising. But until there’s sufficient data to gain FDA approval for TAF to be used for PrEP (in combination with emtricitabine), no provider will write for Descovy for PrEP, and perhaps more importantly, no insurance company will reimburse for Descovy for PrEP.