There are lubes with numbing effects (boy butter I think has sells one). Although I agree with orion boy, poppers and smaller plugs/dildos are best (second to an average sized cock and a hot savvy top pig who knows how to use it).
Poppers are supposed to be short-lived. The trick is the push until you can’t keep going, hold in place and keep the pressure on your hole, a few quick hits and then push a little more to take advantage of the effect.
But everyone is different and as an experienced bottom I know that level of excitement plays a big role. If I’m really uncomfortable or put off, often because of the guy, even taking things that I sucked right in before can be painful and impossible. So keep that in mind.