Longer Term Injectable Prep

[sinfuljock]

Found this interesting. Would make PrEP much more convenient and missed doses less likely (and maybe also decrease cost?) 

 

http://www.towleroad.com/2014/11/research-on-injectable-longer-lasting-prep-moving-forward.html

[Poz1956]

There is more than one antiretroviral being studied as a slow release injectable.

One is in monkey trials and is showing very good results.  But sometimes drugs that work well in an animal model aren't as efficacious in human.  There's a long way to go with that drug.

 

A different antiretroviral is currently in Phase II human trials.  Phase II trials try to determine what dosage to use, and and how different doses are tolerated.  The current trial is trying to determine blood levels of the ARV over time.  It has already discovered that people with a high BMI have lower quantities of the ARV in the blood.  Participants have not yet reached the first three month blood tests.

Phase III trials are where researchers determine IF the drug is effective.

 

We are at least ten years away from injectable PrEP.  It's important research, and hold great promise.  Just don't expect it to reach the market soon.

[wood]

There is more than one antiretroviral being studied as a slow release injectable.

One is in monkey trials and is showing very good results.  But sometimes drugs that work well in an animal model aren't as efficacious in human.  There's a long way to go with that drug.

 

A different antiretroviral is currently in Phase II human trials.  Phase II trials try to determine what dosage to use, and and how different doses are tolerated.  The current trial is trying to determine blood levels of the ARV over time.  It has already discovered that people with a high BMI have lower quantities of the ARV in the blood.  Participants have not yet reached the first three month blood tests.

Phase III trials are where researchers determine IF the drug is effective.

 

We are at least ten years away from injectable PrEP.  It's important research, and hold great promise.  Just don't expect it to reach the market soon.

 

Yeah I am hoping for more like 5 years, but i'm not holding my breath.  Medication trials can a very long time.  It would however be interesting if this would have additional ramifications for HIV+ people.  If they would receive their medication via injection every 3 months that would be a huge help in keeping people on their medication and undetectable.

[Guest JizzDumpWI]

Indeed, every three months could time well with regular Sti tests.

[rawfuckr]

... (and maybe also decrease cost?) 

 

 

LOL

[Poz1956]

Slow release injectable ARV are being considered for Poz guys.  Specifically the ones that are having problems with adherence.  For example think of homeless street youth.  They're more concerned about their next meal, and a roof over their head for the night than taking their meds.

For PrEP, it's kind of a unknown quantity.  Will a guy remember to book/attend his appointment in three months, especially if he only has to think about HIV once every three months?  And what happens if he skips/misses that appointment.  The injectable PrEP level will drop.  If it drops low enough, and gets exposed to HIV, that could lead to drug resistance.

Of course that's the same arguments AHF makes about Truvada for PrEP.  We're beginning to see an interesting trend for guys currently taking PrEP.  Before PrEP many were poorly adherent to other medications they were prescribed.  But their focus on staying negative by taking Truvada every day, is leading to them taking all their other meds every day too.  Yet one more chink in the Weinsteinian arguments.