Can't decide whether or not to get pozzed

[BootmanLA]

21 hours ago, BigChaserHere said:

If you can't swallow your PrEP, consider CABENUVA

First month = IM injection day 1 then IM injection 30 days later

THEN ....

an IM injection every other month

It lends great protection

Cabenuva is *NOT* a PrEP medication. It's for TREATMENT of HIV once you get it. Please don't confuse the issue by conflating PrEP (which is prevention of HIV) with this drug (which is for TREATMENT of HIV).

The injectable form of PrEP is called (by brand name) Apretude, which contains only ONE of the active ingredients in Cabenuva. In fact, as a general rule, PrEP (in any form) contains fewer ingredients than HIV treatment medications. The reason is that it's easier to prevent HIV than it is to treat it - once it's managed to burrow its way in, completely removing it is essentially* impossible, and it requires disrupting the replication of HIV in more than one way. Prevention just has to keep it from taking hold in your system.

*I  say "essentially" because there have been a handful of cases of eradicating HIV, by killing off a patient's entire immune system with chemotherapy and a stem cell transplant to replace it. But that's an expensive, debilitating process that runs the risk of killing the patient and may or may not always succeed. 

[BootmanLA]

15 hours ago, IrishBoi said:

the injection isnt available in the uk here yet

And it's unlikely to be approved as a first-line PrEP product; that is, it's more likely that even when it IS approved and available, you'd be required to take the tablet form until they documented that didn't work well for you given your swallowing issues. You might luck out and get the injection approved from the start, but planning on that is betting on a less-than-likely event.

[rpup]

One thing about getting pozzed and HIV regimens: you don’t really get to choose.  I for example have a mutation which causes HIV to be fully resistant to NNRTI class drugs, like what is half of the medicines in Cabenuva, so there is no complete regimen for me and anyone else who inherited their HIV from people who had trouble with Efavirenz or Nevirapine toxicity and side effects years ago.

Your HIV is genotyped and phenotyped using Stanford’s comprehensive database of HIV mutations, and it will suggest to you what drugs are most effective. YMMV.

[Norcalfukkr]

I’d do the injection, too, if my insurance would cover it. Unfortunately it doesn’t, so then I’m stuck with pills and I’m bad about remembering to take, especially if I’ve been on a weekend binge of sex. When I’m drunk on cock and cum, it’s hard to temper to take a pill. 

[barefucker44]

7 minutes ago, Norcalfukkr said:

I’d do the injection, too, if my insurance would cover it. Unfortunately it doesn’t, so then I’m stuck with pills and I’m bad about remembering to take, especially if I’ve been on a weekend binge of sex. When I’m drunk on cock and cum, it’s hard to temper to take a pill. 

Yep, it is.  Easier to just get pozzed up and forget about it and fuck

[Bwccummer]

I am wondering when Prep injection may possibly be available in the UK. If is to say be in a month to maybe wait a month and get prep injection. If lower or unknown then could be more difficult. 

A alternative maybe is if can travel to learn if injection available in another country like France, Germany. Or I guess if able to travel to United States for injection but I realize cost may not work as a option.

[Guest]

genuine question, sorry if it's a dumb one -- would grinding up the PrEP pill into a powder somehow render it ineffective? If not, could you "take" the pill that way?

[Norcalfukkr]

12 minutes ago, Vancrawman said:

genuine question, sorry if it's a dumb one -- would grinding up the PrEP pill into a powder somehow render it ineffective? If not, could you "take" the pill that way?

Unfortunately, that would change the absorption characteristics of the pharmaceuticals.  They’re in pill form, with a hard outer coating to slow the absorption rate so that the compounds enter the bloodstream through a slow and controlled process.  Having it ground up would make it absorb rapidly but then be flushed out of your  body just as rapidly through your kidneys.  It wouldn’t have the chance to build up a protective concentration in your body.  

[Guest]

4 hours ago, Norcalfukkr said:

Unfortunately, that would change the absorption characteristics of the pharmaceuticals.  They’re in pill form, with a hard outer coating to slow the absorption rate so that the compounds enter the bloodstream through a slow and controlled process.  Having it ground up would make it absorb rapidly but then be flushed out of your  body just as rapidly through your kidneys.  It wouldn’t have the chance to build up a protective concentration in your body.  

Ah, that makes sense! Thanks for that info 😀

[PozBearWI]

PrEP injection....  Yeah that is a pretty cool thing.  Especially for guys who pretty much live at the saunas...  

Cabeneuva starts out with pills though guys...  The plan is to learn how your body responds to a shorter acting version so that we aren't started on something lasting 30 or 60 days and learn you need to be OFF of that stuff immediately.  Once that test has been done the injections can start.  But know that pretty much everyone is reporting a sore but (and that injection has to go into large muscle, so butt is where it goes).  

By contrast a PrEP on demand can meet the needs of MOST.  And done that way one is reducing the amount of medication in our system while still being effective.  For one who has trouble swallowing pills as my hubby does, 2-1-1 can really help.  

 

[Poz50something]

On 10/20/2024 at 9:57 PM, Norcalfukkr said:

I’d do the injection, too, if my insurance would cover it. Unfortunately it doesn’t, so then I’m stuck with pills and I’m bad about remembering to take, especially if I’ve been on a weekend binge of sex. When I’m drunk on cock and cum, it’s hard to temper to take a pill. 

the reality is this - if you become HIV, you are GONNA have to take a pill. I lived for two years without being medicated, and believe me, I have never felt so sick in my life. Therre's the once monthly injection, but I am not sure I am ready for it. 

[BlueSaphir]

NO…you don’t want to get poz. I speak from experience of dealing with AIDS. 

[greo]

On 11/9/2024 at 10:13 AM, Norcalfukkr said:

They’re in pill form, with a hard outer coating to slow the absorption rate so that the compounds enter the bloodstream through a slow and controlled process. 

Truvada is neither enteric coated (to delay its dissolution) nor in an extended/delayed release formulation.

Some people who can't take Truvada tablets are advised to mix it with 100ml of juice or water, OP could ask their doctor what they think, studies say it's fine to.