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FillMyArse

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Everything posted by FillMyArse

  1. Totally agree with Bunker and Cellar for the late evening... found myself in at least one of them most nights I was there, even one of the bar men got to know me quite well!! My arse was anyone's after a few jugs of alcohol at the mainstream bars beforehand!!
  2. Scientist looking at new drug compounds for various diseases and infections, including HIV.
  3. Doesn't the - kill the hashtag? Might just have to go with #bbbhLON or something (no - ) ??
  4. There is some truth in what evilqueerpig was saying. Gilead know about how HIV hides and are trying to develop drugs that invade those hiding spaces... Source: http://www.bloomberg.com/news/articles/2015-08-17/after-curing-hepatitis-c-gilead-works-to-vanquish-more-viruses Gilead Sciences Inc., basking in the success of its cure for hepatitis C, is setting ambitious goals to vanquish two other major viral scourges: HIV and hepatitis B. Even with some promising signs in early trials, the biggest biotechnology firm in the world faces long odds in finding a way to rid humanity of the diseases. And it’s unclear whether a cure for either virus would produce the kind of lucrative return that Gilead has earned from its treatments for hepatitis C. The Foster City, California-based drugmaker has more than doubled its drug sales since 2013 after introducing Sovaldi and Harvoni, which cure more than 90 percent of patients with the liver virus in a matter of weeks. Gilead’s success also has left it with $8.61 billion in cash on hand, and the drumbeat is getting louder for the company to make a large acquisition to support continued growth. The biotech giant’s executives say Gilead is trying to maintain its position on the front lines of battle against the viral illnesses, even as it branches out into new disease areas such as cardiovascular and respiratory conditions. “Gilead is the leader in HIV, and fewer companies are working in HIV now,” said Andrew Cheng, executive vice present of clinical research and development operations. The biotech company dominates the HIV market, estimating that about 80 percent of new patients starting therapy are prescribed a Gilead drug. GlaxoSmithKline Plc, AbbVie Inc. and Johnson & Johnson are competitors. Gilead’s Viread, taken in combination with other drugs in four HIV therapies, will face generic competition in December 2017. To replace it, Gilead is rolling out a new set of treatments based on TAF, an improved version of Viread that achieves the same viral suppression with one-10th the dose, meaning fewer side effects to patients’ kidneys and bones. The TAF-based regimens are expected to start receiving approvals from U.S. regulators in November. Hidden VirusAt the same time, Gilead is working to put the TAF drugs out of business as it pursues a cure. HIV is notoriously tricky to attack -- current treatments suppress virus replication, but the wily virus hides out in latent, or “resting,” cells that the immune system can’t find. With current drugs, when a patient stops treatment, the sleeping cells roar back to life. Gilead’s leading candidate for a cure, GS-9620, employs a tactic known as “kick and kill,” in which latent cells are stimulated into an active mode, Cheng said. Then, in theory, the immune system can recognize the infected cells and kill them. In a study of monkeys presented in February, doses of GS-9620 corresponded with “blips” of viral activity that suggested resting cells were being “woken up,” Cheng said. The drug is now being tried in humans in an early-stage trial, with initial results expected in the first half of 2016. Woodchuck CureGS-9620 is being considered as well as a component of a cure strategy for hepatitis B, a virus that also has evasive tactics that allow it to hide from the immune system. In a study of woodchucks -- animals commonly used for hepatitis B studies - - viral loads were undetectable after four weeks of treatment, giving them a “functional cure” that remained even when treatment was stopped. In a chimpanzee study, a short course of therapy provided long-term viral suppression, encouraging Gilead to move into human trials. There’s no guarantee the drug will end up working for either virus. And while cures could be lucrative, the markets for the diseases are different than for hepatitis C drugs Sovaldi and Harvoni, which generated $4.9 billion in second-quarter sales. Smaller Market? “In the major markets, HIV is now a chronic condition versus the ruthless killer it was decades ago, thanks to many efficacious drugs available today that keep the virus at bay,” said Asthika Goonewardene, a Bloomberg Intelligence analyst. “The need for a ‘cure’ is less critical.” While the hepatitis B population is larger than that of hepatitis C -- about 350 million chronic patients worldwide versus 150 million, according to the World Health Organization - - a greater proportion of hepatitis B patients are in the developing world, where profit margins would be smaller for Gilead, Goonewardene said. On the other hand, the drugs could require a longer treatment time than Sovaldi and Harvoni, resulting in higher price tags for a course, UBS AG analyst Matt Roden said. To continue the momentum Gilead has gotten from Sovaldi and Harvoni, the company will remain under pressure to do deals. “They’re going to have to branch out a bit if they want something to add $2, $3 or $4 billion to the top line over the next few years,” said Phil Nadeau, an analyst at Cowen & Co. Nadeau suggested Gilead look at deals in cancer or lung diseases. Gilead’s work on GS-9620 also may open the door to more acquisitions like the one that made the company the leader in hepatitis C, Roden said. Harvoni combines Gilead’s drug ledipasvir with Sovaldi, which was acquired in the 2012 purchase of Pharmasset Inc. “The blueprint for Gilead’s M&A in the past has been to integrate assets in an area where they have expertise,” said Roden. “It’s the combination of assets that has the most value.”
  5. If there's no ws area, then I'd suggest if you want ws fun... don't spill any! Swallow it or make sure your hole clenches up when he pulls out. Little spillages can get away with the towel to wipe up then just exchange the towel if you want... or keep it in a slightly damp state. That's how I played it anyway.
  6. I've been to the London one once before. You do get a big mix of guys whether young (though not too many in the 'twink' category), old, slim, chubby, muscular and everything in between. Sex seemed pretty free-for-all too which was all part of the fun. Bent over a bench, on a mattress or in the sling my hole got filled numerous times!
  7. HardOn which is held once a month in Vauxhall is a mostly condom free zone and CumUnion in an SE postcode (see their bbrt party posts).
  8. I've got a liver biopsy coming up at the end of the month. Hopefully this will finally be what's needed to get me on treatment.
  9. Only had 2 guys fuck me with a PA before (and it was on the same night). Loved both of them though. Get some real good sensations of warm cock and cold metal. Would love to have more guys with PAs fucking me. As for size, don't know what they were but anysize bring it on I'll take it.
  10. Managed to get a couple of choke sessions in this year, but still no one willing to go as far as making me pass out. Really want someone again to go that extra step with me.
  11. What area are you in? I have a really active gag reflex, and wanna be used like in the 'gag the fag' vids!
  12. Have you also tried Levitra/Staxyn/Vivanza? (all essentially the same drug marketed under different names)
  13. tbh, some of the 'not my type' fucks I've had I've rated as some of the best fucks I've ever had!! But I probably still have to feel a little desperation to go with someone who's not my type in the first place lol... unless I've been in a sling and had a group of guys around me. Then I'm anyones!
  14. Cheers for the clarification... classic case of skim reading rather than digesting the whole matter!! In that case, I'd still probably keep it on the downlow within the sauna... it would still gross guys out IMO again, unless it was a raunchy theme, and then even some would still find it gross. Tbh, I've had it happen to me, by accident.. was being fucked... guy pulls out and shoves his cock in my mouth and I knew in less than a second that I was cleaning up a mix of cum, lube and my own shit. Made me gag a bit, but he seemed to enjoy (possibly even knew his cock came out dirty). He still went back in for another go after! When we had finished I just popped to the loo to douche (if I plan a sauna visit... always take a douche with me for those just in case moments! ). I know the next guy might not like the idea of a dirty arse as much.
  15. Unless a sauna/bathhouse has a scat/raunch theme night, prob best keep to outdoor cruising areas. Smell is prob the biggest put off for people and most are pretty freaked out by shit.
  16. From the title alone I WAS going to say of course it's ok to ask, just be prepared to LOTS of rejection. CumUnion London when I went, there was some condom usage around, a guy tried fucking me with a condom and I just said No thanks and off he went to find someone else. Don't know if he ever did get any action that night! However, with your situation I think the others have summed it up pretty well.. CumUnion is NOT the place for you.
  17. Ahh ok I see. Yeah my last post was based on general population rather than just gay guys.
  18. HepC is not rare. It's actually more prevalent than HIV. Quick google search to official stats will give you estimated numbers. Think for UK it's around 214k people for HepC vs 115k for HIV. (Gov.uk 2014 reports) Unfortunately there's much less info and awareness out there of HepC than HIV.
  19. UK is 16 and I think that's a good age for it. I had sucked at younger age (13) but didn't get fucked till I was 17. Though back then the age of consent for gay sex was 18. I think the majority of people aren't emotionally mature enough under 16. Some still not so even at 16+
  20. It depends on the guy... not necessarily about how hot he is or how hot he finds me (much more often the first option there!) but if the sex was really good then yeah I'm well up for repeat fucks... and also had first time fucks where I've thought definitely not going there again!!! But also had the one time only's that have been awesome and I'm sure I've had more than my fair share of cock! Overall way more often than not the sex I've had has been one time only, simply by the way I've gone about getting sex... mainly cruising, saunas/bathhouses and sex clubs. But the guys I have had multiple fucks with have been for a good reason.
  21. I don't really think its a case of why do gay people use Google more than Bing or other search engine.. I think Google is just more widely used by every demographic than other search engines. I've never heard anyone say to find an answer to something.. Ooh let me Bing/Ask/Yahoo etc that... It's alway been Ooh let me Google that! (maybe less of the Ooh!)
  22. Good to see BBRT has added Neg+HEPx and Poz+HEPx options to profiles. Looks like I'm the first to use this new feature too!
  23. NW1 (Camden) probs not gonna get as slutty. You're just outside the Soho bars area. Try there and also Kings Cross, Vauxhall and SE1/SE11 areas.
  24. Happy New Year to all!! Hope you get to breed / be bred even more than 2014!
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