rawfuckr

Absolutely. During primary syphilis infection you have a chancre, an open wound, usually on your cock (but also can be on your butthole). Perfect entry point for HIV. I'm sure if you have a chancre in makes your chances of getting HIV to grow exponentially.

A postmortem writeup of my first-ever syphilis infection. The big 'S' was the last one I had not got yet. But a while back I noticed this funky not quite right area on the bottom of my glans, where the foreskin starts. It all started when I was getting sucked and it hurt on the right side. I instantly blamed the guy mentally on using teeth and didn't think more of it. It was however on the next fuck when I realize that feeling was there I was thrusting my cock into the guy. Careful inspection revealed pretty much nothing, a red area on behind the glans and between the foreskin. I kept going. A few fucks later and it got worse. Everytime I stuck it in there was this miserable pain like my glans was being ripped apart. At this time red area had become circular and it didn't really hurt on the touch of it. It was only when you stretched it, like when you were fucking, that I'd feel discomfort. It did look like a chancre. I googled images of 'chancre' and it was pretty much that. So off to the GP doctor I went. She was uncomfortable about it, but still ordered VDRL and RPR tests. They came back NEGATIVE. But at this point, I knew that was pretty much syphilis, maybe too early to show up in tests. So I went to specialized STD clinic, and there they were able to do more testing. Bam! One of the treponemal tests came back + and in their inspection of the sample with microscope they could see the bacteria at simple sight, so I had it. Penicillin was given to me right away. I was asked to refrain from sex TWO weeks!!! So I had to look at this better. Apparently Treponema Pallidum is extremely susceptible to penicillin, to the point people stop being infections in a few yours from the shot. At 24-48 hours it's a guarantee you are no longer infectious. So a week of abstinence was more than enough. Penicillin was amazing. Even just after 24 hours after the shot I could see the chancre disappearing. It took probably a couple of weeks for it to be completely gone, but there's just nothing there anymore. In my research I found Treponema Pallidum/Syphilis is no easy cookie. If you let it go it can completely fuck you up. But at the same time, It's probably more treatable than gonorrhea or chlamydia given that there are no known antibiotic resistant variants. The whole experience puts in perspective to me the importance of testing, and testing often. So much of the messaging has been devoted to condoms! condoms! condoms! that people think that condoms are the one and only thing to do not get STDs. When in reality, what everyone should be doing is getting tested and treated as often and possible regardless of condom use. That way we would get STDs down..

Let's set the record straight. Drinking or swallowing cum, poz or not, has exactly zero risk for HIV infection. HIV can only be transmitted directly to an open wound. The throat and digestive track is an incredibly hostile medium for HIV and dies right away. It's an urban myth. You can't get it by swallowing. It's a different story if you get a load in your mouth and nurse it for a while before you spit it out. Now THAT has some risk, if you have open ulcers in the mouth. You maybe giving some chance for HIV to enter the bloodstream. Ironically, this is what most people will do because they think it's safer... Oral sex in general, even when swallowing, nursing loads..., it's a extremely low risk activity for HIV. HIV rates would have been much bigger had that been the case. But if you have any concerns about oral sex and HIV always remember: "Either swallow it or spit it, never keep it"

PrEP veteran here. Almost 5 years now. I used to keep track of hookups and I was averaging 100 loads/year approximately, and if anything pace has picked up in the last few years, So I'm pretty sure I'm hovering the 500 load mark. I take loads from anyone (I still have to fancy them physically though!). I mean I take loads from anyone without asking status or what not. Still very negative. I have picked up gono, clam in the ass, and syphilis on my dick, so didn't get that from bottoming. At any rate, I have zero interest in seroconverting, and I have slutified myself and having the time of my life thanks to PrEP. STDs that have shown up have been dutifully dealt with the regular checkups.

There's no data about this case, other than someone who was in a PrEP study seroconverted. There have been many seroconversions in PrEP studies, the vast majority of them coming from people not taking the pill. Until we know more about this, this means nothing.

I guess your status should be "Neg+PrEP*" with an explanatory *, but given that's not available "Neg+PrEP" should do. Descovy seems to be pretty protective at least from animal models, so you are definitely on some sort of PrEP. Also, PrEP also signifies recurrent STD checking and treatment which you will be getting fully. This is assuming you are on the Descovy arm.

Must have been a tough call for the caregivers, but the fact that he was AB positive was an omnious sign that HIV had taken hold somewhere even if he was PCR negative everywhere. What to do? They ended living him off Truvada and HIV came out of hiding. This case is extremely bizarre. 100% of PrEP seroconversion cases before this one had had resistance to Truvada.

I'm sort of in the same place that you are. Guy had 60 partners/month and was hitting every single drug out there.. BUT the researchers have a pretty good case for strong adherence. He had a daily log, his measured levels were totally consistent with daily dosing, and so were his pill counts. Still the way he turned + is very strange. Got + AB test with negative/UD PCR test, even with very fine lab HIV testing. If he was taking truvada consistently, and from his dry blood spot samples seems he was, how was he able to seroconvert without a significant viral load? No one knows and its a mistery.

http://www.aidsmap.com/page/3118230/ Quite bizarre

very nice. Why only to men under 45? Which one are they giving out? Gardasil 4 or Gardasil 9? Is it free?

This guy didn't poz you. You were HIV+ before this event happened. It takes at the very least two weeks for a 4th gen test to turn +, and PCR test would take about a week. It's very unlikley you got pozzed on friday and were already testing + on monday. You simply were HIV+ before friday.

It is exactly the same. US version is 'Tenofovir Disoproxil Fumarate', EU version is 'Tenofovir Disoproxil' which yields different mg counts. The 'tenofovir disoproxil fumarate' is the prodrug in the pill.. your body metabolizes this down to 'tenofovir disoproxil' which the active ingredient. The different in mgs comes from telling which one you are counting, but they are the same compound with same quantities on the pill. From here https://goo.gl/r4RkjU : Tablet: 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate (equivalent to 245 mg of tenofovir disoproxil): blue, capsule-shaped, film-coated, debossed with "GILEAD" on one side and with "701" on the other side.

I would assume NHS makes their decisions on what drugs to use, in trials done all over, and not just in the UK. There must be lots of drugs which would be impossible to assert efficacy by the UK alone. Thus this argument that NHS needs to 'run their own numbers' to justify cost it's a bit iffy. There have been so many PrEP trials so far that efficacy is beyond any reasonable doubt. I'm surpirsed Truvada already only costs $510 in the UK. My script in USA runs at about $1450/month... from which I pay nothing. I'd think the UK could bring the generic price down a lot in a couple of years! And this is why I think the NHS is just dancing around nothing. They could just pay the brand pricing for a couple of years, avoid lots of people getting HIV, and get into a cost effective situation later. Like what France is doing. And to your last line, yes! PrEP has completely obliberated the HIV+/HIV- divide in the USA. No one cares anymore, because it doesn't matter anymore. Between TASP and PrEP, it's a new world. Myself - I started not thinking about it a couple of years back. But it was a process for me to get to that point. I imagine it will be the same for lots of other people.

What does this actually mean? Is the NHS simply buying some time until the generics arrive and the cost savings from giving PrEP to people vs HIV infections are real?

In the latest case of PrEP seroconversion, the guy kept testing negative on his 3rd gen HIV antibody testing while his PCR was +. 4th gen eventually became poz. So yes, it does seem like PrEP may delay a poz on antibody tests, specially older 3rd generation. Ask your provider to do regular PCR or 4th gen to catch anything asap.

I'd assume double dosing will give you more side effects and not necessarily 'double' the protection. These things get metabolized by your body at a certain rate and maybe part of the extra pill gets just filtered away. That said, it's probably OK for the short term.

I'm sure that did't have anything to do with it.... Frankly, Norway has so much money that I guess for them it was not a difficult choice. Cash strapped systems like NHS and the like are a lot more reticent because of the bottom line.

New case of HIV acquisition this time coming from a prep study in the Netherlands. http://www.gaysite.nl/actueel/2016/10/prep-beschermt-niet-100-procent Little details on this one other than guy got truvada resistant strain...

All details here http://www.thebody.com/content/78607/despite-second-case-of-hiv-prep-still-most-effecti.html TLDR Guy claims 100% bare top (condoms with partner when bottom) Partner +UD comfirmed he didn't get it from partner. claims to have had only two other partners from where he acquired HIV. He was 100% top with them HIV strain he got has resistance mutations for most of the nucleosides and some NNRTIs [non-nucleoside reverse transcriptase inhibitors] adherence tested through hair samples and dry blood spots developing story ...

Poz UD & Neg on PrEP guys are the only guys guaranteed not to give you HIV Everyone else risk is higher. You can't determine who is 'negative' and most poz not medicated guys don't know they are poz... so how to tell them apart? You can't. That's what you have PrEP though. To stop getting HIV in the case you get a High VL poz load. If you want to minizime risks just try to limit your bare play to Poz UD / Neg on PrEP guys.

I'm so hesitant about buying Truvada/Tenvir-EM from indian pharmacies... I bought some ED drugs, viagra/cialis generic, and they do NOTHING compared to the real thing. Did a lot of A/B testing and the 100mg of sildenafil from Alldaychemist (suhagra) did nothing to me while 100mg of generic sildenafil from US (5 x 20mg Revatio) give me a brutally insane hardon This instantly made me not trust Alldaychemist, specially for something like PrEP where you have no feedback on what you are ingesting. I understand some people in London are doing Tenofovir testing to make sure you are taking the real thing, but still leaves a lot of room to suspect that one batch you buy from some random indian pharmacy may be placebo. Europe needs officially sanctioned PrEP now.

Seems you are London based. How/Where are you getting your Truvada pills if you don't mind to share? NHS won't pay for them atm.

I think part of the problem is that the actual mechanism why PrEP works are not completely understood. We know it works, we are not sure why. If it is because of Tenofovir concentration on PMBCs cells, then TAF/Descovy will be a fantastic agent for PrEP.

Is this true? AFAIK There have only been two studies related to TAF (Descovy) and PrEP and they are not too promising. One in monkeys did show Descovy protecting the animals from infection, but when they looked at concentrations of Tenofovir in people through TAF dosing, it was much less than expected, specially in rectal areas. Look at it here https://goo.gl/8eGcJW, But as far as gay breeding goes, this is what matters: "Tenofovir concentrations in rectal tissue were about 10-fold lower with TAF than with TDF. Here, levels peaked by day 3 and remained detectable through the end of the 14-day study period. TFV-DP levels were undetectable in 63% of the rectal samples after TAF dosing but always detectable after TDF dosing" TL;DR TAF(Descovy) produces lower levels of Tenofovir in your butt which may mean less protection. Emphasis on 'may'

Are you uncut? Somehow, after breeding and fucking bare hundreds of asses every year I've never tested + for an STD in my dick.