rawfuckr
-
Posts
539 -
Joined
-
Last visited
Content Type
Profiles
Forums
Blogs
Events
Gallery
Everything posted by rawfuckr
-
Side-effects and cost. If you are HIV+ you are going to put up with side effects just because you have to, but for prevention the side-effect profile really needs to be very favorable. There's also the cost issue.
-
Guys who dont know they are infected don't have med resistant strains, are therefore they will be stopped readily by PrEP. I should look it up, but seems med-resistant strains are not virulent. Add the two, and the case of being infected by someone who's carrying Truvada-resistant HIV sounds very implausible. The biggest problem by far with PrEP is starting it while having just serocoverted. This could very well be the case recently hitting the news; guy didn't get RNA tests on baseline and could have been infected. Antibody test went negative for a while while he was a few months on PrEP and eventually he developed resistance to the drug... If you go on PrEP demand RNA tests, a couple or three weeks apart, while you are starting. You do want a solid negative baseline. This one has been talked about before. The big thing for us to notice here, is that these people were straight, and likely women. For women TDF concentrations in the vaginal area are orders of magnitude less than in rectum, therefore more prone to seroconversions. Also It can't be established how well adherent the people who serocoverted were. They were definitely taking it sometimes but there could have been gaps, we don't know.
-
You have to take a load from someone who is unmedicated and with high VL. Sounds a long stretch. Case looks legit, but he mentions that "I was very ill for about two weeks. I had chills, night sweats, and a horrible cough when it was done. The flu was rampant at the time so I didn't really think much of it." Given his VL was so low <1000 it's just hard to picture why would anyone would have a fuck-flu when they are essentially undetectable. Either he's a phenonemal Bullshitter or just the first known case to get infected while on PrEP.
-
I think anyone, even a NP can issue a prescription. And all you need is quarterly checkups for STDs and kidney. It's totally cool to educate your doctors or NPs about this. They are 'general' practitioners and they don't know everything. The one that thing you really want, is that they are supportive, so the first doctor doesn't sound a good match. Just look for anyone in the clinic and if not go somewhere else.
-
If people can't cough up the courage, some STD clinics provide an 'anonymous' service where they'll call or send a postcard from the clinic saying that someone they've been with tested positive for an STD and they should get checked. I frankly don't have problems telling the tricks I care about. When I broke the news in the past the reaction has been positive. It makes stronger the trustworthiness in the person.
-
Yes, you got chlamydia in the ass from one of those 4 raw fucking instances. Chlamydia, is the most common bacterial STD. Urine test will only detect an STD in the urethra, not in the mouth or in the ass, you need all areas swabbed. PrEP protects you from HIV but nothing else. The good news is most other STDs can easily be treated with antibiotics, so the important thing is to keep getting tested and treated. I'm sure doctor gave you antibiotics that will take care of any chlamydia you may have. It would be cool that you informed your 4 partners about this, because it's 100% sure one of them is infected and should get treated.
-
Prep How Long Have You Been On It, And Are You Still Neg?
rawfuckr replied to Pitt1988's topic in PrEP Discussion
HPV vaccination could still be good regardless of what you hear around that 'if you already got HPV vaccine will do nothing'. Not true. HPV infections are localized and are not blood-borne. While the vaccine can't do anything about a current infection in some area it can still prevent infection in other areas. Also, for Gardasil-9 you may very well have not been infected by any of the 9 types it covers so you'll get immunity to that. Regarding Chlamydia in the butt, most common symptoms are none. Often, the body fights it off and goes away but sometimes it can cause trouble. That's why it's important to get your ass swabbed for gono and clam. -
Prep How Long Have You Been On It, And Are You Still Neg?
rawfuckr replied to Pitt1988's topic in PrEP Discussion
I see I answered this thread a while back, but I'll update. Now, I've been on PrEP for 2 years and a half, (does that make me a PrEP veteran?) Never had any side effects. Took many many loads, and getting fucked raw a lot more often. I can't remember last time I used a condom. Still negative. I did get chlamydia in the butt a couple of times, but went away easily with just one pill (1 gram of Azytromicin). Also HPV is lurking around without much consequence, but HPV is unavoidable if you have any sort of sex... I'm pretty convinced PrEP worked saved me from seroconverting because a lot of the loads happened from random people in bathhouses.. seems like I should have seroconverted by now. -
I move between 9+ hour timezone difference and this became an issue too. I'm a bit paranoid about it so I'll spread the pill taking so it coincides with as much as 24 hours separation as possible, but I think the advice here is solid, simply take it at your usual time in the arrival timezone and call it a day. Shouldn't make much of a difference from what we know. If you want to be ever safer, just don't BB the day of arrival, or the day after.
-
If your partner is undetectable and you are on PrEP, condoms are overkill.
-
Taking Valtrex (For Herpes) Will Lower Your Viral Load
rawfuckr replied to rawTOP's topic in HIV/AIDS & Sexual Health Issues
This is interesting. I take Valtrex + Truvada (for PrEP) so maybe I'm unknowingly on some sort of super prep combo. -
Doctor Talks Condoms To Cumdump
rawfuckr replied to bttmsubslut's topic in HIV/AIDS & Sexual Health Issues
I've thought of this before. Poz guys on meds are essentially on SuperPrEP so has to be impossible for them to get any more strains if they are adhering to their meds. Must have been perfectly true back in the 90s but not anymore. -
What's the actual wording on the paperwork of the test? I'd assume that Oraquick will take longer to show positive than other tests so it's not great for the PrEP protocol. 4th generation testing, and better PCR testing are much better to tell if you got a breakthrough infection or not.
-
Tenofovir levels accumulate over time and peak in the rectal area around 5-6 days, thus they ask for 7 days before risk events. Other areas could be much slower, It's clear now that PrEP doesn't work so well for women but its perfect for receptive anal sex. Even when levels peaks at the 5 day mark you have some sort of protection probably since hours after swallowing the first pill. It just won't be as good as daily usage after a while.
-
It's not clear at all the protection in this study came from the pills right before and after sex, or rather from the accumulated effect over time. The average intake by people in the study was 4 pills/week. Protection observed was 86%. This is right in line with previous studies at 4 pills/week.
-
Horny Being An Undocumented Side Effect Of Prep
rawfuckr replied to colletonguy's topic in PrEP Discussion
Keep talking to people about it. It's the only way to make PrEP more commonplace. I no longer care if someone blows me off because of it, they are now in the minority. Most guys I talk to become super excited about the idea of raw fucking without HIV risk. -
What Is Your Current Hiv Status? (Poll)
rawfuckr replied to a topic in HIV/AIDS & Sexual Health Issues
Have you considered PrEP? -
HepC in gay men is less common than HIV I think which is what I was talking about. But I totally agree everyone should know more about it and get tested. Hopefully the 12 week cure-pill treatments will come down in price sometime soon to make them more accessible.
-
The people at free clinics I've talked with have told me it's a cost issue. Given that Hep C is rare there's always a cost/benefit analysis to be made to see if they should be testing people. From the individual point of view you should be tested regularly, specially if you are on PrEP.
-
Got results back and of the 3 areas biopsied 2 came back with AIN1. They happened to be the areas where the warts were located so it makes lots of sense. The third area was negative for dysplasia. Because doc excised the warts hopefully I could get a normal HRA next year whenever it's due? I'm vaccinated with Gardasil and planning on getting Gardasil-9. If I've been reading correctly, and no one seems to make any emphasis on this, Gardasil will prevent further HPV infections in other areas where you weren't infected, in current infections it does nothing. So if you get your lesions excised, does that mean they won't come back ? I hope that's the case. I'm now scheduled for a follow up in a year.
-
I'll find out next week what's going on with the biopsies. My warts were all inside and they were impossible to see from the outside. They should be gone now because he cut them off.. yay! I'm sort of surprised that this HRA procedure is not performed more often. Seems easy enough, and the disease with serious enough complications to warrant more common screening. Doctor was mentioning the case of a patient that came it at 80 years of age, and not been fucked in 40 years. It didn't matter, because 40 years before he got the HPV infection in the area and after 4 decades it had developed into cancer. Had they caught it a lot earlier it wouldn't have been so much of a problem.
-
Just pinching in on this conversation. Had a 'High Resolution Anascopy' today. This is essentially a dude with a microscope and a tube that goes into your ass to look the walls of your rectum to see what's up. I was convinced everything was going to be normal, but it wasn't. The following is all inside the rectum, nothing abnormal can be seen from the outside. There were tons of warts that the guy was able to remove/cauterize. But then he found a few areas that didn't look right to him and he biopsied them. He mentioned they were probably AIN1 but they could very well be higher.. not particularly reassuring. Getting results in a bit from the biopsies.
-
I don't work in the medical so maybe someone around here can explain further. The tenofovir level in plasma doesn't matter much, where it really matters for PrEP is is in the PBMC cells (http://goo.gl/d4TJqN) which are the ones HIV attacks. You must have sufficient levels of tenofovir inside the CD4 cell to stop the replication process if you were to get infected. While you ingest your daily Truvada pill, tenofovir accumulates in the PBMC cells little by little every day. In the studies they go and take biopsies of tissues to see when maximum concentration levels are achieved. For rectal tissue it happens the fastest, and it's about 5-7 days when it peaks, therefore you get max protection. Other areas, like vaginal tissue take much longer up to 21 days, and even then it never reaches the levels of the rectal areas. I've never seen any mention of levels in the dick. Your intuition is right in the sense that plasma levels of Tenofovir must be pretty much the same all over the body and they saturate pretty quickly, I think in 24 hours or so. What you actually ingest is TDF, which is a prodrug of tenofovir. There's all sort of metabolic hooplas that they have figured out that make it that you end with just tenofovir inside the PBMC which is what you want for treatment and prevention. As far as follow up, the CDC recommends at least screening for STDs every 6 months and continuously check for kidney function. It's just a recommendation and doctors/people will do whatever they see fit. In most states anyone who turns HIV+ must be reported, but I don't think there's nothing specific to if someone is on PrEP or not.
-
There have been a few PrEP breakthrough seroconversion cases, but all involving straight sex and in all of them we can't tell how well their adherence was. There is one particular case of someone who seroconverted with their regular straight partner, and seemed to be taking Truvada regularly because he/she had detectable levels at all meetings of the partners PrEP study. He/she went onto seroconvert AND develop resistance to Truvada. We know he developed resistance due to PrEP because they were able to determined he got infected from the partner through genotyping, and the partner did not have resistant HIV, so resistance happened inside him while taking PrEP. There's a lot to learn still, but PrEP seems to be very effective, specially for bottom gay men. The concentration of Tenofovir in rectal tissue is orders of magnitude greater that in cocks or vaginas so this alone could be a reason why we haven't seen any seroconversions in gay bottoms. It could be that protection is absolute even if you get loads with sky high VLs. We don't know. We do know it is very effective north of 90% with certainty, but can it fail? You are in the absolute highest risk of those who are perfect PrEP adherers having gay sex, so you should really be aware that seroconverting with all we know today and your perfect adherence is still a possibility, specially if you have lots of encounters where you get loaded and most of them seem to be loads with detectable VLs. Only you can answer the question, but how would you life change if you seroconverted? Right now it's a possibility, greatly diminished by your PrEP regimen, but it's there and you should think how you would life change.
-
Finally On Prep, But Still Afraid And Unsure About Bb
rawfuckr replied to Pitt1988's topic in PrEP Discussion
In 2015 many guys out there just don't care about getting HIV. It's not like they are bug chasers or anything, they have simply made the decision that if they get it, so be it, 'there are pills for that now'. Specially older guys that age group 40+. It's really tough to ask a whole generation of gay men to have sex with rubbers and do away with the natural way. For guys over 40, they've gone through the first/second decade of the crisis with pristine condom use, but then as we move forward and HIV becomes less of a problem a lot of people are reassessing. PrEP is great! for this people but will take time to get the word out. It's also particularly involved and lots of folks are not going to bother. People will fall through the cracks. In your case. If you don't feel like you can have an honest conversation about this stuff with someone then don't fuck with them. It's a very good attitude to have.
